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Your search keyword '"Nikolai H. Jung"' showing total 13 results
Start Over Author "Nikolai H. Jung" Journal klinische neurophysiologie
13 results on '"Nikolai H. Jung"'

4. Aufmerksamkeitsabhängige Induktion synaptischer Plastizität bei gesunden Probanden und Patienten mit Noonan Syndrom

Author

Nikolai H. Jung, Volker Mall, Florian Heinen, A Brandt, F Mainberger, L Freudenberg, Igor Delvendahl, and Martin Zenker

Subjects
Physiology (medical), Neurology (clinical)
Abstract

Fragestellung: Das Noonan-Syndrom (NS; OMIM 163950) wird durch Genmutationen verursacht, welche zu einer Hyperaktivitat des Ras-Signalwegs fuhren. Aktuelle in-vitro Studien konnten einen Zusammenhang zwischen beeintrachtigter Langzeitpotenzierung (LTP) und einer Hyperaktivitat des Ras-Signalwegs zeigen. Zusatzlich ist die Induktion synaptischer Plastizitat durch gepaarte assoziative Stimulastion (PAS) beim Menschen stark aufmerksamkeitsabhangig. Daher war es Ziel unserer Studie, die synaptische Plastizitat bei gesunden Probanden sowie Patienten mit NS unter verschiedenen Aufmerksamkeitsbedingungen zu untersuchen.

Published
2013
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5. Lovastatin improves impaired LTP-like plasticity in patients with Neurofibromatosis Type 1

Author

Igor Delvendahl, Volker Mall, T. Winkler, U. Wahlländer, Martin Zenker, Steffen Berweck, Nikolai H. Jung, A. Straube, Florian Heinen, L Freudenberg, and Florian Mainberger

Subjects
medicine.medical_specialty, business.industry, Long-term potentiation, Plasticity, medicine.disease, Endocrinology, Physiology (medical), Internal medicine, medicine, In patient, Neurology (clinical), Lovastatin, Neurofibromatosis, business, medicine.drug
Published
2011
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6. Impaired long term potentiation (LTP)-like plasticity in patients with high functiong autism and Asperger syndrome (HFA/AS)

Author

A Münchau, M Biscaldi-Schäfer, Volker Mall, Tobias Bäumer, Nikolai H. Jung, Florian Mainberger, and R Rauh

Subjects
Asperger syndrome, Physiology (medical), Pediatrics, Perinatology and Child Health, medicine, Autism, In patient, Long-term potentiation, General Medicine, Neurology (clinical), medicine.disease, Psychology, Neuroscience
Published
2010
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7. Impaired motor cortex plasticity in patients with Noonan-Syndrome

Author

F Mainberger, L Freudenberg, Nikolai H. Jung, Martin Zenker, A Brandt, Igor Delvendahl, and Volker Mall

Subjects
medicine.anatomical_structure, business.industry, Physiology (medical), Medicine, Noonan syndrome, In patient, Neurology (clinical), Plasticity, business, medicine.disease, Neuroscience, Motor cortex
Published
2010
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8. Influence of current direction in transcranial magnetic stimulation (TMS) on MEP amplitude and latency – opportunity of I wave specific evaluation and stimulation

Author

Astrid Pechmann, Volker Mall, Igor Delvendahl, and Nikolai H. Jung

Subjects
Physics, Motor threshold, Communication, business.industry, medicine.medical_treatment, Healthy subjects, Stimulation, General Medicine, Stimulus (physiology), Transcranial magnetic stimulation, Amplitude, Nuclear magnetic resonance, Electromagnetic coil, Physiology (medical), Pediatrics, Perinatology and Child Health, medicine, Neurology (clinical), Latency (engineering), Current (fluid), business, Monophasic waveform, Neuroscience
Abstract

Introduction: It has been shown from invasive epidural recordings that in transcranial magnetic stimulation (TMS) a current in the brain flowing from a posterior to an anterior (p.a.) direction mainly evokes I1, I2 and I3 waves whereas a current flowing from an anterior to a posterior direction mainly evokes I3 waves. This leads to the hypotheses that in p.a. current direction the motor threshold (MT) is lower, motor evoked potentials (MEPs) are higher and latency is shorter than in a.p. direction. The aim of this study was to re-evaluate the inconsistent results in literature by means of a stimulation technique that enabled us to change the current direction without turning the coil. Methods: We investigated n=23 healthy subjects (female: n=12; mean age: 26.2±1.9 years). We recorded the MT, MEP amplitude to target 400µV (SI400µV), MT adapted IO curves and maximum stimulator output (MSO) adapted IO curves in a.p. and p.a. current direction (monophasic waveform) with the P-Stim 160 stimulator (Mag and More, Germany). Results: MT was significantly lower (p=0.003), MEP amplitudes (SI400µV) were significantly higher (p

Published
2010
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10. Intrinsic plasticity in human motor cortex

Author

N Kuhnke, F Mainberger, Volker Mall, Ulf Ziemann, Igor Delvendahl, and Nikolai H. Jung

Subjects
medicine.anatomical_structure, Physiology (medical), medicine, Neurology (clinical), Biology, Neuroscience, Intrinsic plasticity, Motor cortex
Published
2010
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11. Vorhergehende niederfrequente Stimulation verhindert bidirektionale Plastizität im motorischen Kortex

Author

N Kuhnke, F Mainberger, M. Cronjaeger, Nikolai H. Jung, Igor Delvendahl, and Volker Mall

Subjects
Physiology (medical), Neurology (clinical)
Abstract

Hintergrund: Die Wechselwirkungen zwischen neuronale Plastizitat induzierenden Protokollen werden durch die Bienenstock-Cooper-Munroe-(BCM)-Theorie beschrieben, nicht hingegen die im Tierexperiment beschriebene Blockade von Long-Term Potentiation (LTP) und Long-Term Depression (LTD) durch niederfrequente Stimulation. Methoden: Repetitive transkranielle Magnetstimulation (rTMS) mit einer Frequenz von 0,1Hz wurde vor Paired Associative Stimulatioon (PAS) mit den Interstimulusintervallen 25ms und 10ms durchgefuhrt (n=10 fur PAS_25ms, n=8 fur PAS_10ms). Bei den gleichen Probanden wurde zum Vergleich nur PAS angewendet. Ergebnisse: PAS_25ms fuhrte zu einer Vergroserung der Amplituden motorisch evozierter Potentiale (MEP) von 1,10mV zu 1,82mV (p

Published
2009
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