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Resume Introduction. – La thrombose intracardiaque est une complication rare de la maladie de Behcet (MB), qui peut se presenter comme une tumeur intracardiaque. Sa decouverte precede, dans la moitie des cas, le diagnostic de MB. La mortalite elevee peut etre en rapport avec des complications postchirurgicales et/ou une atteinte associee des arteres pulmonaires. Exegese. – Nous rapportons l'observation d'une femme francaise caucasienne de 31 ans, aux antecedents de maladie thromboembolique veineuse (MTEV), qui a subi une chirurgie apres la decouverte d'une tumeur du ventricule droit. Il s'agissait d'un thrombus organise avec fibrose endomyocardique et dans les suites operatoires nous avons diagnostique une MB. L'evolution a ete favorable sous traitement medical associant une corticotherapie, de la colchicine et des antivitamines K (AVK), sans recidive quatre ans apres. Conclusion. – La decouverte d'une masse intracardiaque chez un sujet jeune doit faire evoquer le diagnostic de thrombus cardiaque et de maladie de Behcet, meme en l'absence de facteur ethnique ou geographique predisposant.

Resume Les auteurs rapportent deux cas de syndrome de Lambert-Eaton associes a un cancer bronchique a petites cellules. Les donnees concernant le diagnostic clinique sont rappelees. Les acquisitions recentes sur le caractere auto-immun de cette affection, les relations entre le syndrome paraneoplasique et le cancer a petites cellules sont discutees. Ce syndrome est lie a la presence d'anticorps qui bloquent les canaux calciques voltage-dependants des terminaisons nerveuses. Les cellules du cancer a petites cellules expriment des canaux calciques, ces determinants antigeniques induisent probablement la production des anticorps. L'hypothese de l'origine auto-immune de ce syndrome paraneoplasique repose sur la notion d'antigenicite croisee.

Resume Deux cas de femmes jeunes, avec occlusion arterielle aigue du membre superieur droit et diagnostic concomitant de maladie de Basedow sont rapportes. Il s'agit vraisemblablement d'embolies arterielles sur trouble du rythme paroxystique, sans notion de cardiopathie. Le bilan thyroidien doit etre rajoute a la liste des examens complementaires a pratiquer au cours de la demarche etiologique d'une occlusion arterielle chez un sujet jeune sans facteur de risque cardio vasculaire.

Cardiac thrombosis is a rare complication of Behçet's disease (BD), which may present as a cardiac tumor. Its discovery precedes, in half of the cases, the diagnosis of BD. The high mortality may be associated to postsurgical complications and/or an associated involvement of pulmonary arteries.We present the case of a 31 years old Caucasian French woman, with a history of venous thromboembolic disease, who had surgery after the discovery of a right ventricle tumor. That was an organised thrombus with endomyocardial fibrosis and a diagnosis of Behçet's disease was made after the surgery. The outcome was favourable under medical treatment associating corticosteroids, colchicine and antivitamin K (AVK), without relapse four years later.The discovery of an intracardiac mass in a young patient must evoke the diagnosis of cardiac thrombus and Behçet's disease, even in the absence of predisposing ethnic or geographic factor.

We report two observations of young women with concomitant diagnosis of acute arterial occlusion of the upper limb and Graves' disease. The occlusion was probably related to arterial embolism on paroxysmal atrial fibrillation, without underlying cardiopathy. Dosage of thyroid hormones should be performed in case of arterial occlusion in young subjects without cardiovascular risk factors.

We report a series of 40 cases of infectious endocarditis, diagnosed on a 10-year period in a department of Internal Medicine. Initial clinical features were not suggestive of endocarditis and led to delayed hospitalization and diagnosis.

We report two cases of fatal necrotizing vasculitis in patients under 50, with intestinal gangrena resistant to immunosuppressive treatment, plasmapheresis and hyperbar oxygen. Although showing signs of necrotizing arteritis, biopy failed to recognize any specific feature of known vasculitis.

Jaw claudication and clinically abnormal temporal artery are shown to be highly specific of giant cell arteritis with positive biopsy, whereas headache and fever, more commonly seen in negative biopsy arteritis, may reflect the inclusion of non-related pathologies in this group.

We report a set of clinical criteria easily collected at the time of patient's examination, which allow the diagnostic of Giant Cell Arteritis with a sensitivity of 85 % and a positive predictive value of 72,5 % when the biopsy is negative.

We report one case of biopsy-proved large cell arteritis with polyneuropathy and intestinal involvement leading in 15 days to mesenteric ischemia, small bowel perforation, multivisceral failure and death in spite of the administration of high-dose steroids, symptomatic treatment and abdominal surgery.

We report a series of 40 cases of infectious endocarditis, diagnosed on a 10-year period in a department of Internal Medicine. Initial clinical features were not suggestive of endocarditis and led to delayed hospitalization and diagnosis.

33 % of patients giant cell arteritis (Ta and PMR) versus 9 % of controls have been tested positive for anticardiolipine antibodies at the time of diagnosis. Positive patients presented severe vascular complications.

We report a case of a 60-year old woman, with a tracheal stenosis as the first sign of Wegener's granulomatosis. This is the twelfth observation described in the literature.

We report a case of digital necrosis after treatment with diclofenac, regressive after cessation of the drug and steroid therapy. Biological findings were those of a chemically induced lupus.

We report 2 complications of celiac disease, which were the first sign of the disease previously unknown : a B lymphoma and an adenocarcinoma of the small intestine.

We report a case of painless giant cell thyroiditis with inflammatory syndrome, hypothyroidism, and multinodular goiter regressive after steroid treatment. The association with headache rises the question of its relation with giant cell arteritis.