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13. Design and evaluation of flow distributors for microfabricated pillar array columns.

Author

Vangelooven J, De Malsche W, Op De Beeck J, Eghbali H, Gardeniers H, and Desmet G

Abstract

Five different flow distributors have been compared as a function of the flow rate for their ability to distribute small sample volumes over the entire width of flat rectangular microfabricated pillar array columns. The investigated designs can be divided in two major categories: (1) bifurcating, radially non-interconnecting distributors and (2) radially interconnecting distributors consisting of diamond-shaped pillars, elongated in the direction perpendicular to the flow, providing a high ratio of radial permeability over axial permeability. The quality of the flow distribution was evaluated experimentally by injecting equal volumes of fluorescent tracer into each of the tested designs and calculating the obtained peak variances using the method of moments. Purely bifurcating distributors perform less well than the best possible radially interconnected distributors, because the former inevitably require the use of wide open channels (d > 10 microm), wherein a lot of band broadening can occur. By doubling the aspect ratio of the radially stretched pillars from 5 to 10, the measured peak variance drops to 1/8 of the original value. The best results were obtained with a distributor in which the flow is distributed by a bed of anisotropic pillars with an aspect ratio of 10, but our results indicate that a substantial improvement can still be made by increasing the aspect ratio and adding gradually diverging sidewalls to the inlet.

Published
2010
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14. Nanochannels in SU-8 with floor and ceiling metal electrodes and integrated microchannels.

Author

Nichols KP, Eijkel JC, and Gardeniers HJ

Subjects
Electrodes, Hydrophobic and Hydrophilic Interactions, Surface Properties, Temperature, Chromium chemistry, Gold chemistry, Microfluidics instrumentation, Nanotechnology instrumentation
Abstract

Sacrificially etched 2-D nanofluidic channels and nanospaces with integrated floor and ceiling electrodes and arbitrary channel geometries have been demonstrated with channel heights from 20 nm to 400 nm, widths from 800 nm to 40 microm, and lengths up to 3 mm, using SU-8 as the channel structural material.

Published
2008
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