Search

The efficacy of standard therapeutic strategies for Helicobacter pylori(H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of Lactobacilllus paracasei(L. paracasei) HP7, isolated from kimchi, to inhibit H. pylorigrowth. The effects of L. paracaseiHP7 on H. pyloriadhesion and H. pylori-induced inflammation were examined in ACS human gastric adenocarcinoma epithelial cells and a mouse model of H. pyloriSS1 infection. L. paracaseiHP7 reduced H. pyloriadhesion to ACS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. H. pyloricolonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with L. paracaseiHP7. Additionally, L. paracaseiHP7 decreased gastric inflammation and epithelial lesions in the stomach of H. pylori-infected mice. These results demonstrate that L. paracaseiHP7 treatment can inhibit H. pylorigrowth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by H. pyloriinfection.