1. Superficial scrapings from breast tumors is a source for biobanking and research purposes
- Author
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Eva Darai-Ramqvist, Irma Fredriksson, Govindasamy-Muralidharan Karthik, Jonas Bergh, Ran Ma, Gregory Winn, and Johan Hartman
- Subjects
Pathology ,medicine.medical_specialty ,Biomedical Research ,Microarray ,Estrogen receptor ,Breast Neoplasms ,Biology ,Specimen Handling ,Pathology and Forensic Medicine ,Breast cancer ,Cancer stem cell ,Progesterone receptor ,medicine ,Humans ,RNA, Neoplasm ,Epigenetics ,Pathology, Molecular ,Molecular Biology ,Biological Specimen Banks ,Reproducibility of Results ,DNA, Neoplasm ,Sequence Analysis, DNA ,Cell Biology ,DNA Methylation ,medicine.disease ,DNA methylation ,Neoplastic Stem Cells ,Cancer research ,Immunohistochemistry ,Female - Abstract
Breast cancer is a unique tumor disease in terms of the stringent requirement of predictive biomarker assessments. As recommended by current international guidelines, the established markers consist of estrogen receptor (ER), progesterone receptor, human epidermal growth factor and Ki67, and are primarily analyzed by immunohistochemistry. However, new diagnostic methods based on microarray or next-generation sequencing on DNA and mRNA level are gaining ground. These analyses require fresh-frozen tumor tissue that is generally not available from tumors
- Published
- 2014