1. Magnetic Mesoporous Silica Gated with Doped Carbon Dot for Site-Specific Drug Delivery, Fluorescence, and MR Imaging
- Author
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Arindam Pramanik, Megharay Majhi, Rahul K. Das, and Sasmita Mohapatra
- Subjects
Fluorescence-lifetime imaging microscopy ,Materials science ,Gadolinium ,Nanoparticle ,chemistry.chemical_element ,Context (language use) ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Magnetics ,Drug Delivery Systems ,Electrochemistry ,Humans ,General Materials Science ,Spectroscopy ,Optical Imaging ,Surfaces and Interfaces ,Hep G2 Cells ,Mesoporous silica ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Silicon Dioxide ,Magnetic Resonance Imaging ,Carbon ,0104 chemical sciences ,chemistry ,Quantum dot ,Drug delivery ,Nanoparticles ,0210 nano-technology ,Boronic acid - Abstract
Construction of a theranostic agent which integrates multiple modalities with different functions into one entity is challenging from a molecular design and synthesis perspective. In this context, the present paper reports the fabrication of a novel type of multifunctional hybrid nanoparticle composed of magnetic gadolinium oxide–iron oxide core, mesoporous silica shell gated with boronic acid functionalized highly luminescent carbon quantum dot (BNSCQD). The porous silica shell acts as an excellent reservoir for anticancer drug 5-fluorouracil, whereas the BNSCQD cap impressively controls the drug transport under simulated intracellular environment. Furthermore, recognition and fluorescence turn on response of BNSCQD toward cell surface glycan sialyl Lewisa (SLa) enables targeted drug release and excellent fluorescence imaging of SLa overexpressed HePG2 cancer cells. The r1 and r2 relaxivities of the material are found to be 10 and 165 mM–1 s–1 which is comparable to commercially available magnetic resona...
- Published
- 2018