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Introduction: The purpose of this descriptive study was to analyze the clinical, laboratory, anthropometric, and histological results of patients who underwent laparoscopic sleeve gastrectomy (LSG) before and three months after the operation. Materials and Methods: A total of 110 patients who were followed and underwent LSG between January 2021 and December 2021 were included in this study. Body mass index (BMI), waist and hip circumference, soft lean mass (SLM), percent body fat (PBF), and common laboratory parameters were evaluated before and three months after the LSG. Endoscopic biopsies and LSG specimens were examined by the pathology department. Results: The mean age of the patients was 40.8±11.3 years, and 78.4% were female. There was no significant difference in age in terms of gender (p=0.789). The mean age was significantly lower in patients without comorbid diseases and chronic drug use (p<0.001). There was a significant decrease in BMI, PBF, SLM, glucose, HOMA-IR, HbA1c, total cholesterol, and triglyceride values in the third month (all p's <0.001). A significant correlation was observed between PBF% change and SLM% change values at post-op 3rd month (r=0.332, p=0.001). BMI% and PBF% change showed a stronger correlation than BMI% and SLM% change with (r=0.447, p<0.001) and (r=0.253, p=0.016), respectively. Histopathologic findings of LSG revealed gastrointestinal stromal tumor in 2 cases, neuroendocrine hyperplasia in 2 cases, and intestinal metaplasia in 13 cases, which were detected incidentally. Conclusion: LSG is an effective treatment for obesity and associated comorbidities, with significant improvements observed in metabolic parameters, hypertension, and laboratory values. Careful monitoring and follow-up are essential to detect and treat potential histopathologic findings. [ABSTRACT FROM AUTHOR]