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The materials examined by mass spectrometry may have hundreds to thousands of unique components in a wide concentration range. The spectra are very complex--even to a trained eye. Two mass [...]

The contact between food or pharmaceuticals and the packaging that contains them presents a fascinating opportunity for creative chemistry. It also creates a test for analysts. A 2007 issue of [...]

In the days before electrospray (ES) and the rapid growth of mass spectrometry as a premier analysis tool in the life sciences sector, petroleum, polymers and environmental samples were the [...]

History credits the Hughes Research Lab's Theodore Maiman as the first to successfully operate a laser, in 1960. Since then, according to the LaserFest website, the US Patent office has [...]

This month's column addresses some elementary aspects of the mass spectrum, discusses tools used by experienced practitioners and provides some glimpses into current advances in the science and art of [...]

"In retrospect, we sometimes see the successful return of an earlier idea on the back of great advances in technology." ********** In 1997, in an article that appeared in what [...]

"... We will restore science to its rightful place, and wield technology's wonders to raise healthcare's quality and lower its cost. We will harness the sun and the winds and [...]

Part 2 of this three-part series focuses on comparing operation and performance of the most well known mass spectrometers. This month's column continues with Part 2 of the three-part series, [...]

Electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) are now among the most commonly used techniques for creating ions, especially from small-molecule compounds in solution. [...]

Although interpreting MS spectra can be a thorny problem at least some of the time, in the words of Fred McLafferty, 'All you are dealing with is the mass of [...]

Despite the well-considered physics and engineering involved in mass spectrometer technology--that is, in creating ions and passing them through a series of lenses--it nonetheless seems that the quality of one's [...]

Liquid chromatography-mass spectrometry (LC-MS) has been increasingly indispensable in most analytical pursuits. Such acceptance would not have occurred without encouraging, early academic efforts and also the efforts of early practitioners [...]

'Mass spectrometry (MS) is widely appreciated as a powerful analytical method, characterized by high sensitivity and high information content, that can be used for both the qualitative and quantitative analysis [...]

This month's instalment of "MS in Practice" explores the topic of informatics and data management, with Todd Neville and Michael Elliott as featured scientists. Informatics and data management was an [...]

The Centers for Disease Control and Prevention (CDC) estimates that each year in the United States, 76 million people get sick, 325000 are hospitalized and 5000 die from food-related illnesses. [...]

The discovery process is interesting and involved, and in this month's instalment of 'MS in Practice', Michael Balogh continues the Profiles in Practice series by exploring this topic with featured [...]

In this initial instalment of "MS in Practice," a new series of columns is introduced that investigates various aspects of mass spectrometry (MS) from the perspective of some leading practitioners. [...]

This month's 'MS in Practice' provides an overview of several recently developed technologies that will improve the utility and performance of mass spectrometers in a number of applications. The discussion [...]

Mass spectrometrists working in pharmaceutical development tend to approach the issue of regulatory compliance with some trepidation. We know we can't escape its considerable demands for our time and attention, [...]

Achieving greater throughput while increasing informational content figures significantly in most small-molecule practices that lead to medicinally important compounds. Various mechanical increases in productivity, improved software information flow and data [...]

"A well-prepared sample, a well-defined analytical goal, the appropriate use of accurate mass, reproducible retention times and good instrument control generates unassailable data ..." A mass spectrometer's resolution and mass [...]

The spread of liquid chromatography-mass spectrometry as an analytical tool during the past decade has promoted efforts to better accommodate applications. The physical realm of the atmospheric ionization source--materials, gas [...]

'As research advances, about half of what we will teach you ... will turn out to be wrong. The problem is, we presently don't know which half.'--Jerry Avorn, Powerful Medicines, [...]