1. Glucocorticoid administration into the dorsal striatum [corrected] facilitates memory consolidation of inhibitory avoidance training but not of the context or footshock components.
- Author
-
Medina AC, Charles JR, Espinoza-González V, Sánchez-Resendis O, Prado-Alcalá RA, Roozendaal B, and Quirarte GL
- Subjects
- Animals, Avoidance Learning physiology, Corpus Striatum drug effects, Corticosterone administration & dosage, Corticosterone antagonists & inhibitors, Cues, Dose-Response Relationship, Drug, Drug Administration Schedule, Electroshock, Fear, Injections, Male, Mifepristone administration & dosage, Mifepristone pharmacology, Photic Stimulation, Rats, Rats, Wistar, Reaction Time drug effects, Reaction Time physiology, Receptors, Glucocorticoid drug effects, Receptors, Glucocorticoid physiology, Retention, Psychology drug effects, Retention, Psychology physiology, Avoidance Learning drug effects, Corpus Striatum physiology, Corticosterone pharmacology
- Abstract
It is well established that glucocorticoid administration into a variety of brain regions facilitates memory consolidation of fear-conditioning tasks, including inhibitory avoidance. The present findings indicate that the natural glucocorticoid corticosterone administered into the dorsal striatum (i.e., caudate nucleus) of male Wistar rats produced dose- and time-dependent enhancement of inhibitory avoidance memory consolidation. However, as assessed with a modified inhibitory avoidance procedure that took place on two sequential days to separate context training from footshock training, corticosterone administration into the dorsal striatum did not enhance memory of either the contextual or aversively motivational aspects of the task.
- Published
- 2007
- Full Text
- View/download PDF