1. Antiviral activity of Distictella elongata (Vahl) Urb. (Bignoniaceae), a potentially useful source of anti-dengue drugs from the state of Minas Gerais, Brazil.
- Author
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Simões LR, Maciel GM, Brandão GC, Kroon EG, Castilho RO, and Oliveira AB
- Subjects
- Animals, Brazil, Dengue drug therapy, Humans, Mice, Viruses drug effects, Antiviral Agents pharmacology, Bignoniaceae chemistry, Dengue Virus drug effects, Plant Extracts pharmacology
- Abstract
Aims: To investigate the in vitro antiviral activity of Distictella elongata (Vahl) Urb. ethanol extracts from leaves (LEE), fruits (FEE), stems and their main components., Methods and Results: The antiviral activity was evaluated against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), vaccinia virus Western Reserve (VACV-WR) and dengue virus 2 (DENV-2) by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. LEE presented anti-HSV-1 [EC(50) 142.8 ± 5.3 μg ml(-1); selectivity index (SI) 2.0] and anti-DENV-2 activity (EC(50) 9.8 ± 1.3 μg ml(-1) ; SI 1.5). The pectolinarin (1) isolated from LEE was less active against HSV-1 and DENV-2. A mixture of the triterpenoids ursolic, pomolic and oleanolic acids was also obtained. Ursolic and oleanolic acids have shown antiviral activity against HSV-1. A mixture of pectolinarin (1) and acacetin-7-O-rutinoside (2) was isolated from FEE and has presented anti-DENV-2 activity (EC(50) 11.1 ± 1.6 μg ml(-1) ; SI > 45). Besides the antiviral activity, D. elongata has disclosed antioxidant effect., Conclusions: These data shows that D. elongata has antiviral activity mainly against HSV-1 and DENV-2, besides antioxidant activity. These effects might be principally attributed to flavonoids isolated., Significance and Impact of the Study: Distictella elongata might be considered a promising source of anti-dengue fever phytochemicals., (© 2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.) more...
- Published
- 2011
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