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Your search keyword '"Falda, M"' showing total 3 results
Start Over Author "Falda, M" Journal leukemia
3 results on '"Falda, M"'

1. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)

Author

Aoudjhane, M, Labopin, M, Gorin, N C, Shimoni, A, Ruutu, T, Kolb, H-J, Frassoni, F, Boiron, J M, Yin, J L, Finke, J, Shouten, H, Blaise, D, Falda, M, Fauser, A A, Esteve, J, Polge, E, Slavin, S, Niederwieser, D, Nagler, A, and Rocha, V

Published
2005
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2. Outcome of patients activating an unrelated donor search: the impact of transplant with reduced intensity conditioning in a large cohort of consecutive high-risk patients

Author

Rambaldi, A, Bacigalupo, A, Fanin, R, Ciceri, F, Bonifazi, F, Falda, M, Lambertenghi-Deliliers, G, Benedetti, F, Bruno, B, Corradini, P, Alessandrino, P E, Iacopino, P, Arcese, W, Scimè, R, Raimondi, R, Sica, S, Castagna, L, Lamparelli, T, Oneto, R, Lombardini, L, Pollichieni, S, Algarotti, A, Carobbio, A, Sacchi, N, and Bosi, A

Published
2012
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3. Outcome of patients with acute myeloid leukemia who failed to respond to a single course of first-line induction therapy: a GIMEMA study of 218 unselected consecutive patients. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto

Author

Liso V, Iacopino P, Avvisati G, Mc, Petti, Broccia G, Carotenuto M, Falda M, Fazi P, Lazzarino M, Leoni P, Mirto S, Pucci G, Nobile F, Am, Nosari, Giorgina Specchia, Stasi R, Tabilio A, and Mandelli F

Subjects
Male, Salvage Therapy, Remission Induction, Cytarabine, Middle Aged, Prognosis, Combined Modality Therapy, Treatment Outcome, Doxorubicin, Leukemia, Myeloid, Acute Disease, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Bone Marrow Transplantation, Retrospective Studies
Abstract

The outcome of a cohort of 218 consecutive patients who failed to respond to a single course of standard daunorubicin plus ARAC (three + seven) induction regimen has been retrospectively evaluated to assess the characteristics of this group of AML patients and the effectiveness of second-line induction programs. Seventy-four of the 218 patients (33.9%) attained complete remission with salvage chemotherapies. The multivariate analysis of pretherapy characteristics of the patients showed that peroxidase positivity and age were the most important factors in determining whether or not the patient would have a favorable response to second-line induction regimen. In addition, comparison of marrow characteristics at diagnosis with those of marrow after the first-line therapy (marrow leukemic index, MLI) provided the greatest differences between second-line CR and resistant patients. Finally, peroxidase positivity and MLI predicted for remission duration and overall survival. Allogeneic BMT, however, appeared the most important factor for survival and event-free survival of remitting patients. These results are of importance when considering that better defined prognostic factors provide an objective rationale for selecting appropriate strategies for the treatment of patients who do not respond to a single course of induction regimen.

Published
1996

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