1. CLL-like B-lymphocytes are systematically present at very low numbers in peripheral blood of healthy adults
- Author
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Santiago Muñoz-Criado, Arancha Rodríguez-Caballero, A. López, Carlos E. Pedreira, Ana Belen Nieto, Cristina Teodosio, Wendy G. Nieto, Alberto Orfao, Paulino Fernández-Navarro, Alfonso Romero, Julia Almeida, and María Jara-Acevedo
- Subjects
Cancer Research ,medicine.medical_specialty ,Pathology ,Hematology ,business.industry ,Chronic lymphocytic leukemia ,Cancer ,medicine.disease ,Peripheral blood ,Oncology ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,Immunology ,medicine ,business ,neoplasms - Abstract
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world. The disease is typically diagnosed in adults >40 years old, who show an expansion (>5 × 109 cells per l) of clonal B-cells with a unique CD5+, CD23+, B-cell receptor (BCR)low immunophenotype in peripheral blood (PB) and bone marrow, frequently in association with involvement of other lymphoid tissues, disease symptoms and a heterogeneous clinical outcome.
- Published
- 2011
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