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Your search keyword '"Loughran, Thomas P."' showing total 1 results
Start Over Author "Loughran, Thomas P." Topic hematopoietic stem cell transplantation Language english Journal leukemia & lymphoma

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1 results on '"Loughran, Thomas P."'

1. Potential clinical application of imatinib mesylate in patients with leukemic large granular lymphocytes.

Author

Yang, Jun and Loughran, Thomas P.

Subjects
*T cells, *HEMATOPOIETIC stem cell transplantation, *PLATELET-derived growth factor, *PROTEIN-tyrosine kinases, *CHRONIC myeloid leukemia, *PATIENTS
Abstract

In this article the authors comment on the study by Fedele and colleagues on the expansion of cytotoxic T lymphocyte (CTL) in allogeneic hematopoietic stem cell transplant recipients. The authors predict that the platelet-derived growth factor receptor (PDGFR) and receptor tyrosine kinases (RTKs) may play a role in large granular lymphocyte (LGL) leukemia patients. However, there is an expansion of LGLs in chronic myeloid leukemia (CML) patients which are treated wtih RTK inhibitors.

Published
2011
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