1. Non-gastric extra-nodal marginal zone lymphomas-a single centre experience on 76 patients.
- Author
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Kalpadakis, Christina, Pangalis, Gerassimos A., Vassilakopoulos, Theodoros P., Kyrtsonis, Maria-Christina, Siakantaris, Marina P., Kontopidou, Flora N., Korkolopoulou, Penelope, Bobotsis, Panagia, Sahanas, Sotirios, Tzenou, Tatiana, Anagnostou, Dimitra, Dimitriadou, Evangelia, Yiakoumis, Xanthi, Patsouris, Evangelos, Roussou, Panagiota, Panayiotidis, Panayiotis, Papadaki, Eleni, and Angelopoulou, Maria K.
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LYMPHOID tissue , *CLINICAL medicine research , *B cell lymphoma , *LYMPH nodes , *BONE marrow - Abstract
In the present study, we assessed the clinical and pathological data of 76 patients with the diagnosis of non-gastric extranodal marginal zone B-cell lymphoma. The most commonly affected sites were salivary glands, skin, ocular adnexa, lung, intestine and Waldeyer's ring. Ann Arbor stage I disease was present in 39 patients (51%), stage II in 10 (13%) and stage IV in 27 (36%). In 17 cases (21%), the lymphoma presented at multiple mucosal sites. Lymph node and bone marrow involvement were present in 21% and 16%, respectively. Most cases were in the low or low-intermediate risk group. Treatment was heterogeneous and included chlorambucil in 59% either alone or in combination with other agents. Complete and partial remission was achieved in 79% and 7%, respectively, with an overall response rate of 86%. The 5- and 10-year overall survival and cause-specific survival rates were 94%, 82% and 95%, 91%, respectively. The 5- and 10-year progression free survival was 56% and 41%, respectively. The only feature associated with inferior outcome was disease localisation to the lung. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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