1. Autologous hematopoietic stem cell transplantation with inadequate stem cell dose in patients with non-Hodgkin lymphoma.
- Author
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Liu, Weiping, Wu, Meng, Xie, Yan, Zhang, Chen, Ping, Lingyan, Feng, Feier, Leng, Xin, Mi, Lan, Wang, Xiaopei, Zhu, Jun, and Song, Yuqin
- Subjects
HEMATOPOIETIC stem cell transplantation ,STEM cell transplantation ,HEMATOPOIETIC stem cells ,NON-Hodgkin's lymphoma - Abstract
Little is known regarding the outcome of lymphoma patients undergoing autologous hematopoietic stem cell transplantation (AHSCT) using inadequate hematopoietic stem cell (HSC) doses. Fifty-six patients were enrolled in the study, and the cohort was subdivided into two groups according to the infusion dose: < 1 × 10
6 /kg (poor HSC group) and 1–2 × 106 /kg (unfavorable HSC group). Compared with the unfavorable group, the poor HSC group had a longer median time to neutrophil (13 vs. 11 days, p =.007) and platelet engraftment (17 vs. 13 days, p =.024). CD34+ cell infusion dose of < 1 × 106 /kg was the only risk factor for neutrophil and platelet engraftment. The expected 3-year progression-free survival and overall survival rates for the whole cohort were 53% and 66%, and no statistical difference was observed between two groups. In conclusion, inadequate HSC infusion dose did not negatively impact AHSCT patient survival but significantly prolonged the time to hematopoietic engraftment. [ABSTRACT FROM AUTHOR]- Published
- 2021
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