1. Clinical Factors Predictive of Bone Marrow Involvement in Hodgkin's Disease
- Author
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Angelo Maiolino, Wolmar Pulcheri, Marcio Nucci, Mário Alberto Costa, Nelson Spector, José Carlos Morais, and Rodrigo Portugal
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Adolescent ,Anemia ,Spleen ,Disease ,Leukocyte Count ,Predictive Value of Tests ,hemic and lymphatic diseases ,Biopsy ,medicine ,Humans ,Bone Marrow Diseases ,Aged ,Retrospective Studies ,Univariate analysis ,Leukopenia ,medicine.diagnostic_test ,business.industry ,Urban Health ,Hematology ,Middle Aged ,medicine.disease ,Hodgkin Disease ,United States ,Bone marrow examination ,medicine.anatomical_structure ,Oncology ,Multivariate Analysis ,Female ,Bone marrow ,medicine.symptom ,business ,Brazil - Abstract
The role of bone marrow biopsy in the staging of Hodgkin's disease is undergoing reevaluation. We have studied the relationship of clinical factors to the presence of bone marrow involvement in 130 previously untreated patients with Hodgkin's disease. The presence of fever, spleen enlargement, anemia, leukopenia, poor performance status and poor histologic subgroups were positively correlated with the presence of bone marrow involvement in the univariate analysis. In the multivariate analysis, only fever, spleen involvement, leukopenia and poor histologic subgroups were significant. The predictive value of the absence of fever in regard to the absence of bone marrow involvement was 98%. The likelihood of bone marrow involvement in the absence of all four significant factors was only 0.05%. Patients without these clinical factors should probably not be submitted to a bone marrow biopsy as part of the staging procedures performed in Hodgkin's disease.
- Published
- 1997
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