1. PD-L1/PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma.
- Author
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Paiva, B, Azpilikueta, A, Puig, N, Ocio, E M, Sharma, R, Oyajobi, B O, Labiano, S, San-Segundo, L, Rodriguez, A, Aires-Mejia, I, Rodriguez, I, Escalante, F, de Coca, A G, Barez, A, San Miguel, J F, and Melero, I
- Subjects
CARCINOGENESIS ,ANTIGENS ,BONE marrow ,CANCER relapse ,CELL culture ,CELL physiology ,IMMUNOPHENOTYPING ,KILLER cells ,MICE ,MULTIPLE myeloma ,PROGNOSIS ,STEM cells ,SURVIVAL ,T cells ,TUMOR classification ,MULTIDIMENSIONAL Health Locus of Control scales ,METABOLISM - Abstract
The article discusses research that defined the expression of PD-L1 and PD-1 in clonal PCs and T and natural killer (NK) cells on bone marrow (BM) aspirates from monoclonal gammopathy of undetermined significance (MGUs) and multiple myeloma (MM) patients at diagnosis following treatment and upon relapse using standardized multidimensional flow cytometry (MFC). It suggests that PD-L1 can operate as an immune checkpoint in the tumor microenvironment.
- Published
- 2015
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