Search

• In this study, leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) were integrated to IPS-3 system and 2 scores named as IPS-4 were created; IPS-4 with PNI and IPS-4 with LLR. • There was an acceptable agreement between IPS-3 and IPS-7 groups and IPS-4. • These findings need to be confirmed with other studies and the incorporation of pre-therapy PET/CT metabolic parameters including total lesion glycolysis and total metabolic tumor volume to IPS-4 scores may be more informative and may help to predict response to first-line therapy. The aim of this study is to determine the power of he international prognostic scoring systems (IPS-7 and IPS-3) and to obtain indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) factors as prognostic indicators in cases with classical Hodgkin lymphoma (cHL). 1012 patients with cHL were evaluated with 2 different IPS-4 scores with four parameters: stage, age, hemoglobin level, and either LLR or PNI. Statistical package SPSS v 22.0 was used. Two different Cox regression models were obtained for OS and PFS. Model 1 showed LLR ≥ 5,8 as the highest risk for OS and anemia as the highest risk for PFS. Model 2 showed PNI ≤ 45,2 as the highest risk for OS and anemia as the highest risk for PFS. IPS-4 scores obtained by integrating either LLR or PNI to IPS-3 integration of a biologic parameter either LLR or PNI need to be determined with clinical risk scoring parameters. [ABSTRACT FROM AUTHOR]

• HL is one of the rare curable entities in adults with 80% long term survival chance and risk scoring before planning the management of the patients is very important. • There is significant improvement both in diagnostic imaging modalities including PET/CT and also treatments including targeted and immunotherapeutic approaches for this unique entity. • Despite these significant improvement in outcomes, 20% of the patients have refractory disease or show relapse. • Clinicians need an ideal scoring system to identify the risk of every patient and the most commonly used clinical scoring system for a long time for this aim in cHL is IPS-7 and this scoring system has been replaced by IPS-3 system. • Here it has been reported IPS-3 scoring system has been evaluated and validated in 1012 cases. The aim of this study is to validate the IPS-3 scoring system as a prognostic indicator in 1012 patients with advanced stage classical Hodgkin Lymphoma (cHL) treated by doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD). According to the IPS-3 scoring system only 3.5 % had high risk and 50.8 % had low risk disease disease and 45.8 % of the cases had intermediate risk disease. Each factors of IPS-7 and IPS-3 scoring systems (age, sex, stage hemoglobin, albumin, lymphocyte count and white cell count) were found to be significant for overall survival (OS) and progression free survival (PFS) according to univariate analyses. Two different multivariate Cox analyses were performed for OS and PFS including the IPS-3/ IPS-7 scoring system parameters. Among 7 risk factors of IPS scoring system, gender and albumin were not found as independent risk factors for both OS and PFS according to cox regression model. But all parameters such as age, stage and hemoglobin those included in IPS-3, were found to be independent significant risk factors for both models obtained for OS and PFS. The results of the study shows that the IPS-3 scoring system can be used as a prognostic indicator in ABVD treated patients in every day practice which is more easily calculate according to the IPS-7. [ABSTRACT FROM AUTHOR]