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Start Over Author "Alo, F." Journal leukemia research
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6. Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.

Author

Hohaus S, Giachelia M, Massini G, Vannata B, Criscuolo M, Martini M, D'Alo' F, Voso MT, Larocca LM, and Leone G

Subjects
Adult, DNA, Neoplasm genetics, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections diagnosis, Female, Gene Amplification, Genetic Variation, Herpesvirus 4, Human genetics, Herpesvirus 4, Human isolation & purification, Hodgkin Disease complications, Hodgkin Disease pathology, Homozygote, Humans, Interleukin-10 blood, Male, Middle Aged, Neoplasm Staging, Prognosis, Hodgkin Disease genetics, Interleukin-10 genetics, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Promoter Regions, Genetic
Abstract

We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.

Published
2009
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