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Your search keyword '"Pacini, Simone"' showing total 4 results
Start Over Author "Pacini, Simone" Journal leukemia research
4 results on '"Pacini, Simone"'

3. Bone and bone marrow interactions: hematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide III. Action on human megakaryocytopoiesis: focus on essential thrombocythemia

Author

Fazzi, R, Galimberti, Sara, Pacini, Simone, Testi, Rossana, Azzara', Antonio, Orciuolo, E, Trombi, Luisa, Metelli, M. R., and Petrini, Mario

Subjects
Histones, Platelet-Derived Growth Factor, Transforming Growth Factor beta1, Structure-Activity Relationship, Osteoblasts, Bone Marrow, Cytokines, Humans, Intercellular Signaling Peptides and Proteins, Endorphins, Megakaryocytes, Cell Proliferation, Thrombocythemia, Essential
Abstract

The increase of megakaryocytes and platelets that characterizes essential thrombocythemia (ET) appears to be secondary to a deregulation of megakaryocytopoiesis. The carboxy-terminal fragment of osteogenic growth peptide (OGP10-14) promotes bone formation and hemopoiesis, while it inhibits megakaryocytopoiesis. In this paper we show that treatment with synthetic OGP10-14 (sOGP10-14) induces a significant reduction of mid and large colony-forming unit-megakaryocytes (CFU-Mk) in ET patients as well as in controls, and is associated with a significant inhibition of thrombopoietin (TPO)-primed MO-7e megakaryoblastic cells proliferation. These actions appear to be related to sOGP10-14 modulation of TGF-beta(1) synthesis and/or secretion, although a direct effect on TGF-beta receptor expression cannot be excluded.

Published
2003

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