1. Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma
- Author
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Yuetsu Tanaka, Jun-Nosuke Uchihara, Yukiko Nishi, Kennosuke Karube, Masaki Hayashi, Iori Tedokon, Takashi Miyagi, Satoko Morishima, Shugo Sakihama, Takuya Fukushima, Keita Tamaki, Mineki Saito, Sawako Nakachi, Shigeko Kinjo, Takeaki Tomoyose, Naoya Taira, Hiroaki Masuzaki, Megumi Kuba-Miyara, and Kazuho Morichika
- Subjects
0301 basic medicine ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Genotype ,viruses ,Kaplan-Meier Estimate ,Biology ,Gastroenterology ,Polymerase Chain Reaction ,Virus ,Adult T-cell leukemia/lymphoma ,03 medical and health sciences ,Japan ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Leukemia-Lymphoma, Adult T-Cell ,Aged ,Aged, 80 and over ,Human T-lymphotropic virus 1 ,Performance status ,Hazard ratio ,Hematology ,Gene Products, tax ,Middle Aged ,medicine.disease ,Prognosis ,HTLV-I Infections ,Confidence interval ,Lymphoma ,Leukemia ,030104 developmental biology ,Oncology ,Immunology ,Female ,Polymorphism, Restriction Fragment Length - Abstract
Okinawa, comprising remote islands off the mainland of Japan, is an endemic area of human T-cell leukemia virus type I (HTLV-1), the causative virus of adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). We investigated the tax genotype of HTLV-1 among 29 HTLV-1 carriers, 74 ATL patients, and 33 HAM patients in Okinawa. The genotype distribution-60 (44%) taxA cases and 76 (56%) taxB cases-differed from that of a previous report from Kagoshima Prefecture in mainland Japan (taxA, 10%; taxB, 90%). A comparison of the clinical outcomes of 45 patients (taxA, 14; taxB, 31) with aggressive ATL revealed that the overall response and 1-year overall survival rates for taxA (50% and 35%, respectively) were lower than those for taxB (71% and 49%, respectively). In a multivariate analysis of two prognostic indices for aggressive ATL, Japan Clinical Oncology Group-Prognostic Index and Prognostic Index for acute and lymphoma ATL, with respect to age, performance status, corrected calcium, soluble interleukin-2 receptor, and tax genotype, the estimated hazard ratio of taxA compared with taxB was 2.68 (95% confidence interval, 0.87-8.25; P=0.086). Our results suggest that the tax genotype has clinical value as a prognostic factor for aggressive ATL.
- Published
- 2017