1. Clinical efficacy of irradiation in CLL patients: predictive value of in vitro radio-induced apoptosis
- Author
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Catherine Grandpeix, Régis Peffault de Latour, Emmanuel Blot, Jozo Delic, Didier Decaudin, Janine Dumont, Jean-Marc Cosset, Bernard Dubray, and Gérard Tertian
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Chronic lymphocytic leukemia ,medicine.medical_treatment ,Apoptosis ,Refractory ,medicine ,Humans ,Lymph node ,Aged ,Aged, 80 and over ,business.industry ,Hematology ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,In vitro ,Staining ,Radiation therapy ,medicine.anatomical_structure ,Oncology ,Toxicity ,Cancer research ,Female ,business - Abstract
In order to identify CLL patients for whom irradiation could be beneficial, we investigated the relationship between in vitro radio-induced apoptosis of leukemic cells and response to low-dose splenic or lymph node radiotherapy. Fourteen patients were included in the in vitro study. Leukemic cells were analyzed by Hoechst staining immediately after collection or 24 h of culture following in vitro irradiation of 0-10 Gy. The tumor response rate was 47% (one CR and six PR), with a mean duration of response of 3 months (range: 1-4). A high correlation between tumor response and in vitro tests was observed (p more...
- Published
- 2002