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Start Over Author "Katherine Monkman" Journal leukemialymphoma
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1. Treatment of Hodgkin lymphoma with adriamycin, bleomycin, vinblastine and dacarbazine without routine granulocyte-colony stimulating factor support does not increase the risk of febrile neutropenia: a prospective cohort study

Author

Leonard Minuk, Alejandro Lazo-Langner, Vinai Bhagirath, Benjamin Chin-Yee, Katherine Monkman, Joy Mangel, and Ian Chin-Yee

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Neutropenia, Adolescent, Fever, Dacarbazine, Cost-Benefit Analysis, Bleomycin, Vinblastine, chemistry.chemical_compound, Young Adult, Risk Factors, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, medicine, Humans, Prospective Studies, Aged, Aged, 80 and over, business.industry, Hematology, Middle Aged, medicine.disease, Hodgkin Disease, Surgery, Granulocyte colony-stimulating factor, Treatment Outcome, Oncology, ABVD, chemistry, Doxorubicin, Absolute neutrophil count, Female, business, Febrile neutropenia, medicine.drug
Abstract

Although patients with Hodgkin lymphoma treated with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy frequently develop neutropenia, febrile neutropenia is uncommon. Three retrospective trials reported that ABVD could be safely administered without dose delays or granulocyte-colony stimulating factor (G-CSF) support. We retrospectively reviewed the charts of 89 patients treated with ABVD and found that the incidence of febrile neutropenia was 0.5% (five of 927 treatments). This prompted a change to our institutional policy so that patients receiving ABVD no longer receive routine G-CSF for uncomplicated neutropenia. We then prospectively assessed the safety of this policy change. Thirty-three patients received a total of 327 ABVD treatments, 185 (57%) of which were administered with a neutrophil count

Published
2011

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