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Your search keyword '"Genovese, Arturo"' showing total 6 results
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6 results on '"Genovese, Arturo"'

4. Erythropoietin production by the liver in fetal-neonatal life

Author

Arturo Genovese, Cesare Peschle, Gianni Marone, Cristina Magli, Clemente Cillo, Mario Condorelli, Peschle, C, Marone, G, Genovese, Arturo, Cillo, C, Magli, C, Condorelli, M., C., Peschle, Marone, Gianni, C., Cillo, C., Magli, and M., Condorelli

Subjects
medicine.medical_specialty, Spleen, Kidney, General Biochemistry, Genetics and Molecular Biology, Pregnancy, Internal medicine, medicine, Animals, General Pharmacology, Toxicology and Pharmaceutics, Hypoxia, Erythropoietin, Fetus, business.industry, General Medicine, Hypoxia (medical), Liver regeneration, Liver Regeneration, Rats, Endocrinology, medicine.anatomical_structure, Neonatal life, Animals, Newborn, Liver, Female, medicine.symptom, business, Hormone, medicine.drug
Abstract

Subtotal ablation of the liver in 10-day-old ( i.e. , neonate) rats resulted in almost complete abolition of the erythropoietin (Ep) response to a 6-hr bout of hypoxia, starting 1 hr after the operation. Partial or subtotal liver regeneration on day 2 or 3 post-hepatectomy was correlated respectively with partial or subtotal restoration of Ep production. Ablation of the spleen or kidneys in 7- or 10-day-old rats did not modify hypoxic Ep levels. It is concluded that the liver is the main or exclusive source of Ep in the neonate rat, and possibly represents the main site of hormonal production in fetal-neonatal life of mammals.

Published
1975

5. Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion

Author

Oreste Marino, Gianni Marone, Arturo Genovese, Raffaele Cirillo, Stefano Quattrin, Marone, G, Cirillo, R, Genovese, Arturo, Marino, O, and Quattrin, S.

Subjects
Adult, medicine.medical_specialty, Adenosine, 2-Chloroadenosine, Vasodilator Agents, Prostaglandin, Adenosine-5'-(N-ethylcarboxamide), Biology, Histamine Release, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Internal medicine, medicine, Humans, Secretion, Mast Cells, General Pharmacology, Toxicology and Pharmaceutics, Lung, Skin, Leukotriene, Leukotriene C4, Prostaglandin D2, General Medicine, Immunoglobulin E, Mast cell, Basophils, medicine.anatomical_structure, Endocrinology, chemistry, Phenylisopropyladenosine, SRS-A, Nucleoside, Histamine, medicine.drug
Abstract

5'-N-ethylcarboxamideadenosine (NECA) greater than 2-chloroadenosine greater than adenosine greater than N6-(R-phenyl-isopropyl)-adenosine (R-PIA) inhibited in vitro anti-IgE-induced histamine and peptide leukotriene C4 (LTC4) release from human basophils in a concentration-dependent fashion. Micromolar concentrations of adenosine, NECA and R-PIA potentiated the anti-IgE-stimulated release of histamine and LTC4 from human lung parenchymal mast cells. Submillimolar concentrations of adenosine, NECA and R-PIA inhibited in a concentration dependent manner the release of histamine and prostaglandin D2 (PGD2) from skin mast cells challenged with anti-IgE. These results demonstrate marked heterogeneity of the modulatory effect exerted by adenosine on mediator release from human basophils and mast cells.

Published
1989

6. Enhanced erythroid burst formation in mice after testosterone treatment

Author

Clemente Cillo, F. Pizzella, Cesare Peschle, Arturo Genovese, Maria Cristina Magli, Andrea Soricelli, Federico Lettieri, Peschle, C, Magli, Mc, Cillo, C, Lettieri, F, Pizzella, F, Genovese, Arturo, and Soricelli, A.

Subjects
Testosterone propionate, Single administration, medicine.medical_specialty, medicine.drug_class, Polycythemia, Biology, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Mice, Bone Marrow, Internal medicine, Testosterone treatment, medicine, Animals, Erythropoiesis, Testosterone, General Pharmacology, Toxicology and Pharmaceutics, General Medicine, Compartment (chemistry), Androgen, Endocrinology, chemistry, Erythropoietin, Female, Stem cell, Spleen, medicine.drug
Abstract

A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36–49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.

Published
1977

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