1. Lesions of the cholinergic nuclei in the rat basal forebrain: Excitotoxins vs. an immunotoxin
- Author
-
Leon J. Thal and Jerene J. Waite
- Subjects
Male ,medicine.medical_specialty ,Neurotoxins ,Cholinergic Agents ,Hippocampus ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Prosencephalon ,Immunotoxin ,Internal medicine ,Reaction Time ,medicine ,Animals ,Learning ,Receptors, Cholinergic ,Quisqualic acid ,General Pharmacology, Toxicology and Pharmaceutics ,Cholinergic neuron ,N-Glycosyl Hydrolases ,Neurons ,Basal forebrain ,Medial septal nucleus ,Immunotoxins ,Antibodies, Monoclonal ,General Medicine ,Saporins ,Rats, Inbred F344 ,Rats ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Ribosome Inactivating Proteins, Type 1 ,Cholinergic ,Neuroscience ,Ibotenic acid - Abstract
Infusion of the excitotoxins, ibotenic acid, quisqualic acid, or AMPA, into the medial septal nucleus, diagonal band, and the nucleus basalis magnocellularis of rats produced less cholinergic cell loss as assessed by choline acetyltransferase activity in the projection fields, cortex and hippocampus, than that obtainable by intraventricular administration of the immunotoxin,IgG-saporin. All excitotoxins produced reductions in tissue levels of some monoamines, while no decreases were found for the immunotoxin. All toxins produced acquisitional impairment in the hidden platform water maze. This behavioral deficit was slightly greater for the excitotoxic-lesioned rats than for those given IgG-saporin at a dose which produced ChAT depletions similar to the most potent excitotoxin (AMPA). This supports the idea that some of the behavioral effects produced by excitotoxic lesions are due to the cholinergic basal forebrain lesion and some are due to noncholinergic damage.
- Published
- 1996