1. [Characteristics of polyamine biosynthesis regulation and tumor growth rate in hormone-dependant grafted breast tumors of mice and rats].
- Author
-
Orlovskiĭ AA
- Subjects
- Animals, Antineoplastic Agents administration & dosage, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Biogenic Polyamines antagonists & inhibitors, Cell Line, Tumor, Eflornithine administration & dosage, Eflornithine pharmacology, Eflornithine therapeutic use, Female, Guanidines administration & dosage, Guanidines pharmacology, Guanidines therapeutic use, Mice, Neoplasm Transplantation, Ornithine Decarboxylase Inhibitors, Rats, Adenocarcinoma drug therapy, Adenocarcinoma metabolism, Adenocarcinoma pathology, Biogenic Polyamines biosynthesis, Carcinoma 256, Walker drug therapy, Carcinoma 256, Walker metabolism, Carcinoma 256, Walker pathology, Mammary Neoplasms, Experimental drug therapy, Mammary Neoplasms, Experimental metabolism, Mammary Neoplasms, Experimental pathology, Neoplasms, Hormone-Dependent drug therapy, Neoplasms, Hormone-Dependent metabolism, Neoplasms, Hormone-Dependent pathology
- Abstract
Effect of the inhibitors of polyamines biosynthesis on completely or partially hormone-dependant breast tumors (mouse Ca755 carcinoma and Walker W-256 carcinosarcoma) is essentially special: in contrary to hormone-dependant tumors, this effect may be not only breaking but stimulating as well. Change-over from one to another mode of reaction is conditioned, most probable, by hormonal status, which is determined by one or another estral cycle phase. Biochemical mechanisms of this change-over are closely connected with polyamines metabolism, namely the degree of polyamines (especially spermine) interconvertion and physiological reactivity level of the system controlling expression of ornithin-decarboxilase. At that, the first of these pathways is predominant for completely hormone-dependant Ca755 and the second one -for partially hormone-dependant W-256.
- Published
- 2007