1. [The effect of transcardiac galvanization on energy metabolism and the size of the area of the heart muscle lesion in experimental myocardial infarct].
- Author
-
Maslov AG, Karpov RS, Smirnov VP, Laptev BI, and Metelkin AV
- Subjects
- Animals, Disease Models, Animal, Electrodes, Histocytochemistry, Male, Myocardial Infarction enzymology, Myocardial Infarction pathology, Oxidation-Reduction, Rats, Rats, Wistar, Electric Stimulation Therapy instrumentation, Electric Stimulation Therapy methods, Energy Metabolism, Myocardial Infarction therapy, Myocardium enzymology, Myocardium pathology
- Abstract
A study was made of effects of transcardiac galvanization (TCG) on activities of a panel of oxidation-reduction enzymes as well as on the cardiac muscle content of high energy substrates, and size of the lesion area, in experimental myocardial infarction (EMI) in 50 albino male rats. After two TCG procedures, and at 24-h EMI, augmentation was found of activities of succinic dehydrogenase, lactate dehydrogenase, NADH-dehydrogenase, beta-hydroxybutyrate dehydrogenase, both in the area of profound ischemia and peri-infarction myocardium, this being accompanied with an increase in myocardial content of adenosine triphosphate, creatine phosphate, and glycogen, and reduction of the developing mass of necrosis. Stimulation of enzyme activity in the course on the enzyme complex and membrane-stabilizing action of this preformed physical factor.
- Published
- 1995