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Start Over Author "Dongqing Jiang" Journal lipids in health and disease
3 results on '"Dongqing Jiang"'

1. Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis

Author

Dianhui Wang, Ling Wang, Zhanqing Wang, Shihong Chen, Yihong Ni, and Dongqing Jiang

Subjects
Nonalcoholic steatohepatitis, Non-HDL-c/HDL-c ratio, Cohort study, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background Non-HDL-cholesterol to HDL-cholesterol (non-HDL-c/HDL-c) ratio is a feasible predictor for coronary heart disease, metabolic syndrome, and insulin resistance. Patients with nonalcoholic steatohepatitis (NASH) have an increased risk of developing cardiovascular problems and type 2 diabetes. However, the predictive role of non-HDL-c/HDL-c ratio in NASH hasn’t been investigated yet. Methods We conducted a retrospective cohort study. A total of 3489 eligible subjects were selected in the present study. Prevalence and characteristics of NASH were demonstrated. Conditional logistic regression was used to analyze the association between non-HDL-c/HDL-c ratio and risks of NASH. Associations between non-HDL-c/HDL-c ratio and serum aminotransferase levels were also investigated. Results The overall prevalence of NASH was 6.13%, higher in male (6.89%) than that in female (5.04%). Interestingly, the prevalence of NASH showed a positive correlation with the elevation of non-HDL-c/HDL-c ratio (Pearson’s Chi-squared test, linear trend 0.010, p

Published
2018
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2. Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis

Author

Shihong Chen, Ling Wang, Yihong Ni, Zhanqing Wang, Dianhui Wang, and Dongqing Jiang

Subjects
Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Blood Pressure, Type 2 diabetes, 030204 cardiovascular system & hematology, Gastroenterology, Body Mass Index, Cohort Studies, 0302 clinical medicine, Endocrinology, Non-alcoholic Fatty Liver Disease, Risk Factors, lcsh:RC620-627, biology, Confounding, Alanine Transaminase, Middle Aged, lcsh:Nutritional diseases. Deficiency diseases, 030211 gastroenterology & hepatology, lipids (amino acids, peptides, and proteins), Female, Cohort study, Adult, medicine.medical_specialty, digestive system, 03 medical and health sciences, Insulin resistance, Internal medicine, medicine, Non-HDL-c/HDL-c ratio, Humans, Aspartate Aminotransferases, Nonalcoholic steatohepatitis, business.industry, Research, Biochemistry (medical), Cholesterol, HDL, nutritional and metabolic diseases, Retrospective cohort study, Cholesterol, LDL, medicine.disease, digestive system diseases, Alanine transaminase, biology.protein, Metabolic syndrome, business, Body mass index, Biomarkers
Abstract

Background Non-HDL-cholesterol to HDL-cholesterol (non-HDL-c/HDL-c) ratio is a feasible predictor for coronary heart disease, metabolic syndrome, and insulin resistance. Patients with nonalcoholic steatohepatitis (NASH) have an increased risk of developing cardiovascular problems and type 2 diabetes. However, the predictive role of non-HDL-c/HDL-c ratio in NASH hasn’t been investigated yet. Methods We conducted a retrospective cohort study. A total of 3489 eligible subjects were selected in the present study. Prevalence and characteristics of NASH were demonstrated. Conditional logistic regression was used to analyze the association between non-HDL-c/HDL-c ratio and risks of NASH. Associations between non-HDL-c/HDL-c ratio and serum aminotransferase levels were also investigated. Results The overall prevalence of NASH was 6.13%, higher in male (6.89%) than that in female (5.04%). Interestingly, the prevalence of NASH showed a positive correlation with the elevation of non-HDL-c/HDL-c ratio (Pearson’s Chi-squared test, linear trend 0.010, p

Published
2018

3. Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway

Author

Zhanqing Wang, Yihong Ni, Fudun Sun, Dongqing Jiang, Shihong Chen, Dianhui Wang, and Xianghua Zhuang

Subjects
0301 basic medicine, medicine.medical_specialty, Berberine, Clinical chemistry, Endocrinology, Diabetes and Metabolism, Lipolysis, Clinical Biochemistry, AMP-Activated Protein Kinases, 03 medical and health sciences, chemistry.chemical_compound, Mice, ATGL, 0302 clinical medicine, Endocrinology, Internal medicine, 3T3-L1 Cells, medicine, Adipocytes, Animals, Obesity, Lipase, Protein kinase A, HSL, Biochemistry, medical, biology, Research, Biochemistry (medical), 3T3-L1 cell, AMPK, food and beverages, 3T3-L1, Sterol Esterase, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Adipose triglyceride lipase, biology.protein, Signal Transduction
Abstract

Background Obesity is closely related to the metabolism of triacylglycerol (TG) in adipocytes. Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are rate-limiting enzymes that control the hydrolysis of TG. Effects on ATGL and HSL to increase lipolysis may counteract obesity. Berberine (BBR) is a compound derived from the Chinese medicine plant Coptis chinensis. In the present study we show the effects of BBR on ATGL and HSL and explore the potential underlying mechanisms of these effects. Methods The TG content in cells was measured using a colorimetric assay. The expressions of HSL, ATGL and GPAT3 were evaluated by Western-blotting. The expression of ATGL was also evaluated by real-time PCR and radioimmunoassay. Compound C, an inhibitor of AMP-activated protein kinase (AMPK), was used to explore the possible pathway that involved in the effect of BBR on ATGL. Results TG content of differentiated 3T3-L1 cells was significantly decreased by more than 10% after treated with BBR. In differentiated 3T3-L1 adipocytes, BBR increased the expression of p-HSL and ATGL, and these effects were time-depended (p

Published
2016

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