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Oligocene and Miocene Himalayan anatexis is generally thought to have been induced by intracrustal heating or processes without the involvement of mantle-derived heat and materials, suggesting that the Himalayan leucogranites are typical examples of purely crustal melts. This study focuses on a Miocene leucogranite at Langkazi within the Himalayan orogen, an intrusion that contains a large number of dioritic enclaves. These enclaves have typical igneous textures, contain acicular apatites, and have back-veining structures, quenched margins, and crystallization ages identical to the hosting two-mica granites, indicating that these enclaves are magmatic. Although the enclaves are evolved, the most primitive samples contain high concentrations of MgO (up to 4.3 wt.%), Cr (up to 159 ppm), and Ni (up to 102 ppm), are strongly enriched in large-ion lithophile elements, are depleted in high-field-strength elements, have negative ε Nd(t) values (–8.6 to –6.1), and have relatively high 87 Sr/ 86 Sr (i) values (0.7085–0.7137), suggesting that they were derived from a relatively enriched region of the lithospheric mantle source. Whole-rock geochemical data indicate that the hosting Langkazi leucogranite formed from magmas generated by the partial melting of metapelite material within the High Himalaya crystalline sequence, and these magmas subsequently mixed with mantle-derived melts that are now represented by the Langkazi dioritic enclaves. This indicates that mantle-derived material played an important role in the generation of the Langkazi intrusions. The whole-rock geochemical compositions of samples from the study area also indicate that the primary melts that formed the Langkazi enclaves were significantly contaminated by the relatively juvenile Himalayan lower crustal material, suggesting in turn that these mantle-derived magmas underwent MASH (crustal melting, melt assimilation, magma storage, and homogenization) processes at the base of crust, introducing heat to the lower crust. This mantle-derived heat may have induced partial melting of the Himalayan lower crust, forming adakite-like magmas. Although the small volumes of these dioritic enclaves suggest that this heat may have assisted the genesis of the north Himalayan granites and the High Himalayan leucogranites, whereas in situ crustal radiogenic heating, shear heating, and decompression melting dominated the melting processes in this region. [ABSTRACT FROM AUTHOR]