1. The importance of cofactors in the histologic progression of minimal and mild chronic hepatitis C
- Author
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Amar P. Dhillon, Gunnar Norkrans, Steven Shev, Rune Wejstål, Anders Widell, Zita Serléus, and Magnus Lindh
- Subjects
Adult ,Male ,Hepatitis B virus ,medicine.medical_specialty ,Pathology ,Cirrhosis ,Adolescent ,Alcohol Drinking ,Biopsy ,Hepacivirus ,Gastroenterology ,Liver disease ,Internal medicine ,Humans ,Medicine ,Hepatitis B Antibodies ,Hepatitis, Chronic ,Hepatology ,medicine.diagnostic_test ,business.industry ,virus diseases ,Hepatitis C ,Middle Aged ,Hepatitis B ,Prognosis ,medicine.disease ,Histologic Progression ,Liver biopsy ,Hepatocellular carcinoma ,DNA, Viral ,Disease Progression ,RNA, Viral ,Female ,business - Abstract
A follow-up liver biopsy was done 9-16 years (mean 12 years) after initial biopsy in 20 untreated Swedish patients infected with hepatitis C (8 men, 12 women; mean age 30 years at initial biopsy) in whom first biopsy had been classified as chronic persistent hepatitis. A significant progression of liver damage was found when using Histology Activity Index (HAI) scoring according to Knodell (p=0.006 for total HAI score; p=0.03 for grading, i.e., sum of HAI components 1, 2, and 3; p=0.01 for staging, i.e., HAI component 4, fibrosis). Fourteen of 20 (70%) patients had increased while 6 had decreased or unchanged HAI scores on follow-up biopsy. Occasional heavy alcohol drinkers (n=6) had an increased follow-up HAI score as compared with nondrinkers (p
- Published
- 2008
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