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22 results on '"Lauterio A"'

1. Are there any benefits of prolonged hypothermic oxygenated perfusion?: Results from a national retrospective study.

Author

De Carlis, Riccardo, Lauterio, Andrea, Schlegel, Andrea, Gringeri, Enrico, Patrono, Damiano, Camagni, Stefania, Dondossola, Daniele, Pezzati, Daniele, Olivieri, Tiziana, Pagano, Duilio, Bongini, Marco, Montanelli, Paolo, Ravaioli, Matteo, Bernasconi, Davide, Valsecchi, Maria Grazia, Baccarani, Umberto, Cescon, Matteo, Andorno, Enzo, Mazzaferro, Vincenzo, and Gruttadauria, Salvatore

Published
2025
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2. Recipient hepatectomy technique may affect oncological outcomes of liver transplantation for hepatocellular carcinoma.

Author

Pravisani, Riccardo, De Martino, Maria, Mocchegiani, Federico, Melandro, Fabio, Patrono, Damiano, Lauterio, Andrea, Di Francesco, Fabrizio, Ravaioli, Matteo, Zambelli, Marco Fabrizio, Bosio, Claudio, Dondossola, Daniele, Lai, Quirino, Zanchetta, Matteo, Dingfelder, Jule, Toti, Luca, Iacomino, Alessandro, Nicolae, Sermed, Ghinolfi, Davide, Romagnoli, Renato, and De Carlis, Luciano

Published
2024
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3. Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

Author

Damiano Patrono, Riccardo De Carlis, Alessandro Gambella, Francesca Farnesi, Alice Podestà, Andrea Lauterio, Francesco Tandoi, Luciano De Carlis, Renato Romagnoli, Patrono, D, De Carlis, R, Gambella, A, Farnesi, F, Podesta, A, Lauterio, A, Tandoi, F, De Carlis, L, and Romagnoli, R

Subjects
normothermic machine perfusion, liver transplantation, Transplantation, Hepatology, Surgery
Abstract

End-ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for liver transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not been specifically assessed. Prospectively maintained databases at two high-volume LT centers in Northern Italy were searched to identify cases of end-ischemic NMP performed to test the viability of livers with MaS ≥ 30% in the period from January 2019 to January 2022. A total of 14 cases were retrieved, representing 57.9% of NMP and 5.7% of all machine perfusion procedures. Of those patients, 10 (71%) received transplants. Two patients developed primary nonfunction (PNF) and required urgent re-LT, and both were characterized by incomplete or suboptimal lactate clearance during NMP. PNF cases were also characterized by higher perfusate transaminases, lower hepatic artery and portal vein flows at 2 h, and a lack of glucose metabolism in one case. The remaining eight patients showed good liver function (Liver Graft Assessment Following Transplantation risk score, -1.9 [risk, 13.6%]; Early Allograft Failure Simplified Estimation score, -3.7 [risk, 2.6%]) and had a favorable postoperative course. Overall, NMP allowed successful transplantation of 57% of livers with moderate-to-severe MaS. Our findings suggest that prolonged observation (≥6 h) might be required for steatotic livers and that stable lactate clearance is a fundamental prerequisite for their use.

Published
2022
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4. Location and allocation

Author

Artzner, Thierry, Bernal, William, Belli, Luca S, Conti, Sara, Cortesi, Paolo A, Sacleux, Sophie‐Caroline, Pageaux, George‐Philippe, Radenne, Sylvie, Trebicka, Jonel, Fernandez, Javier, Perricone, Giovanni, Piano, Salvatore, Nadalin, Silvio, Morelli, Maria C, Martini, Silvia, Polak, Wojciech G, Zieniewicz, Krzysztof, Toso, Christian, Berenguer, Marina, Iegri, Claudia, Invernizzi, Federica, Volpes, Riccardo, Karam, Vincent, Adam, René, Faitot, François, Rabinowich, Liane, Saliba, Faouzi, Meunier, Lucy, Lesurtel, Mickael, Uschner, Frank E, Michard, Baptiste, Coilly, Audrey, Meszaros, Magdalena, Poinsot, Domitille, Besch, Camille, Schnitzbauer, Andreas, De Carlis, Luciano G, Fumagalli, Roberto, Angeli, Paolo, Arroyo, Vincente, Fondevila, Constantino, Duvoux, Christophe, Jalan, Rajiv, Viganò, Raffaella, Mazzarelli, Chiara, Lauterio, Andrea, Giacomoni, Alessandro, Donato, Francesca, Lampertico, Pietro, Pasulo, Luisa, Fagiuoli, Stefano, Colledan, Michele, Cristina Morelli, Maria, Vitale, Giovanni, Ottobrelli, Antonio, Patrono, Damiano, Romagnoli, Renato, Petridis, Ioannis, Cillo, Umberto, Germani, Giacomo, Burra, Patrizia, Bachellier, Philippe, Schneider, Francis, Castelain, Vincent, Addeo, Pietro, Deridder, Mathilde, Caroline Sacleux Audrey Coilly, Sophie, Faouzi, Saliba, Adam, Rene, Samuel, Didier, Guichon, Celine, Faure, Stéfanie, Ursic‐Bedoya, Josè, Fondevila, Costantino, Colmenero, Jorde, Toapanta, David, Hernández‐Tejero, María, Vinaixa, Carmen, Polak, Wojciech G., den Hoed, Caroline, Haan, Jubi E., Della Penna, Andrea, Erhard Uschner, Frank, Welker, Martin, Zeuzem, Stefan, Bechstein, Wolf, Goossens, Nicolas, Raszeja‐Wyszomirska, Joanna, Rabinovich, Liane, Katarey, Dev, Agarwal, Banwari, Surgery, Gastroenterology & Hepatology, Intensive Care, Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), the ELITA/EF-CLIF Working Group, Artzner, T, Bernal, W, Belli, L, Conti, S, Cortesi, P, Sacleux, S, Pageaux, G, Radenne, S, Trebicka, J, Fernandez, J, Perricone, G, Piano, S, Nadalin, S, Morelli, M, Martini, S, Polak, W, Zieniewicz, K, Toso, C, Berenguer, M, Iegri, C, Invernizzi, F, Volpes, R, Karam, V, Adam, R, Faitot, F, Rabinowich, L, Saliba, F, Meunier, L, Lesurtel, M, Uschner, F, Michard, B, Coilly, A, Meszaros, M, Poinsot, D, Besch, C, Schnitzbauer, A, De Carlis, L, Fumagalli, R, Angeli, P, Arroyo, V, Fondevila, C, Duvoux, C, Jalan, R, Viganò, R, Mazzarelli, C, Lauterio, A, Giacomoni, A, Donato, F, Lampertico, P, Pasulo, L, Fagiuoli, S, Colledan, M, Cristina Morelli, M, Vitale, G, Ottobrelli, A, Patrono, D, Romagnoli, R, Petridis, I, Cillo, U, Germani, G, Burra, P, Bachellier, P, Schneider, F, Castelain, V, Addeo, P, Deridder, M, Caroline Sacleux Audrey Coilly, S, Faouzi, S, Samuel, D, Guichon, C, Faure, S, Ursic‐bedoya, J, Colmenero, J, Toapanta, D, Hernández‐tejero, M, Vinaixa, C, den Hoed, C, Haan, J, Della Penna, A, Erhard Uschner, F, Welker, M, Zeuzem, S, Bechstein, W, Goossens, N, Raszeja‐wyszomirska, J, Rabinovich, L, Katarey, D, and Agarwal, B

Subjects
Transplantation, ILL CIRRHOTIC-PATIENTS, Liver transplantation, Hepatology, Intensive care, Waiting list, Surgery, Acute-on-Chronic Liver Failure, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

There is growing evidence that liver transplantation (LT) is the most effective treatment for acute-on-chronic liver failure grade-3 (ACLF-3). This study examines whether and how this evidence translates into practice by analyzing the variability in intensive care unit (ICU) admissions, listing strategies, and LT activity for patients with ACLF-3 across transplantation centers in Europe. Consecutive patients who were admitted to the ICU with ACLF-3, whether or not they were listed and/or transplanted with ACLF-3, between 2018 and 2019 were included across 20 transplantation centers. A total of 351 patients with ACLF-3 were included: 33 had been listed prior to developing ACLF-3 and 318 had not been listed at the time of admission to the ICU. There was no correlation between the number of unlisted patients with ACLF-3 admitted to the ICU and the number listed or transplanted while in ACLF-3 across centers. By contrast, there was a correlation between the number of patients listed and the number transplanted while in ACLF-3. About 21% of patients who were listed while in ACLF-3 died on the waiting list or were delisted. The percentage of LT for patients with ACLF-3 varied from 0% to 29% for those transplanted with decompensated cirrhosis across centers (average = 8%), with an I(2) index of 68% (95% confidence interval, 49%-80%), showing substantial heterogeneity among centers. The 1-year survival for all patients with ACLF-3 was significantly higher in centers that listed and transplanted more patients with ACLF-3 (>10 patients) than in centers that listed and transplanted fewer: 36% versus 20%, respectively (p = 0.012). Patients with ACLF-3 face inequity of access to LT across Europe. Waitlisting strategies for patients with ACLF-3 influence their access to LT and, ultimately, their survival.

Published
2022
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5. Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

Author

Paolo Muiesan, Massimo Rossi, Damiano Patrono, F. Melandro, Daniele Pezzati, Markus Selzner, Alberto Zanella, Andrea Lauterio, Riccardo De Carlis, Cristiano Quintini, Stefano Baroni, Domenico Bassi, Davide Ghinolfi, Paolo Magistri, Fabio Ferla, Luca Toti, Marinella Zanierato, Matteo Ravaioli, Quirino Lai, Chiara Lazzeri, Wayel Jassem, Patrizia Burra, Daniele Dondossola, Duilio Pagano, Philippe Dutkowski, Umberto Cillo, Erion Rreka, Salvatore Petta, University of Zurich, Ghinolfi, Davide, Ghinolfi, D, Lai, Q, Dondossola, D, De Carlis, R, Zanierato, M, Patrono, D, Baroni, S, Bassi, D, Ferla, F, Lauterio, A, Lazzeri, C, Magistri, P, Melandro, F, Pagano, D, Pezzati, D, Ravaioli, M, Rreka, E, Toti, L, Zanella, A, Burra, P, Petta, S, Rossi, M, Dutkowski, P, Jassem, W, Muiesan, P, Quintini, C, Selzner, M, Cillo, U, Ghinolfi D., Lai Q., Dondossola D., De Carlis R., Zanierato M., Patrono D., Baroni S., Bassi D., Ferla F., Lauterio A., Lazzeri C., Magistri P., Melandro F., Pagano D., Pezzati D., Ravaioli M., Rreka E., Toti L., Zanella A., Burra P., Petta S., Rossi M., Dutkowski P., Jassem W., Muiesan P., Quintini C., Selzner M., and Cillo U.

Subjects
medicine.medical_specialty, Evidence-based practice, 2747 Transplantation, GRADE, donor after circulatory death, donor brain death, hypothermic machine, liver transplant, machine perfusion, normothermic machine, normothermic regional perfusion, position paper, medicine.medical_treatment, Delphi method, MEDLINE, 610 Medicine & health, liver, perfusion machine, 030230 surgery, Liver transplantation, liver, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Medical physics, 10217 Clinic for Visceral and Transplantation Surgery, HumansItaly, Transplantation, Machine perfusion, Hepatology, business.industry, Organ Preservation, perfusion machine, Institutional review board, Liver Transplantation, 2746 Surgery, Perfusion, Italy, Position paper, 2721 Hepatology, 030211 gastroenterology & hepatology, Surgery, business, Human
Abstract

The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and its proper clinical use has far to go to be widely implemented. The Società Italiana Trapianti d’Organo (SITO) promoted the development of an evidence-based position paper. A 3-step approach has been adopted to develop this position paper. First, SITO appointed a chair and a cochair who then assembled a working group with specific experience of MP in LT. The Guideline Development Group framed the clinical questions into a patient, intervention, control, and outcome (PICO) format, extracted and analyzed the available literature, ranked the quality of the evidence, and prepared and graded the recommendations. Recommendations were then discussed by all the members of the SITO and were voted on via the Delphi method by an institutional review board. Finally, they were evaluated and scored by a panel of external reviewers. All available literature was analyzed, and its quality was ranked. A total of 18 recommendations regarding the use and the efficacy of ex situ hypothermic and normothermic machine perfusion and sequential normothermic regional perfusion and ex situ MP were prepared and graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. A critical and scientific approach is required for the safe implementation of this new technology.

Published
2020
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8. Donor safety in living donor liver donation: An Italian multicenter survey

Author

Lauterio, Andrea, Di Sandro, Stefano, Gruttadauria, Salvatore, Spada, Marco, Di Benedetto, Fabrizio, Baccarani, Umberto, Regalia, Enrico, Melada, Ernesto, Giacomoni, Alessandro, Cescon, Matteo, Cintorino, Davide, Ercolani, Giorgio, Rota, Matteo, Rossi, Giorgio, Mazzaferro, Vincenzo, Risaliti, Andrea, Pinna, Antonio Daniele, Gridelli, Bruno, and De Carlis, Luciano

Published
2017
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11. Coronaviruses and Immunosuppressed Patients: The Facts During the Third Epidemic

Author

E. Roselli, Massimo Puoti, Andrea Lauterio, Giovanni Perricone, Luca S. Belli, Luciano De Carlis, Giovanna Travi, Marco Merli, M. Prosperi, Laura Petrò, Merli, M, Perricone, G, Lauterio, A, Prosperi, M, Travi, G, Roselli, E, Petrò, L, De Carlis, L, Belli, L, and Puoti, M

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Disease, 030230 surgery, Liver transplantation, medicine.disease_cause, Immunocompromised Host, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, medicine, Humans, liver transplant recipients, Infection control, Epidemics, Letters to the Editor, Coronavirus, interstitial pneumonia, Transplantation, Hepatology, business.industry, Immunosuppression, Virology, infection control, Liver Transplantation, Immunology, 030211 gastroenterology & hepatology, Surgery, Coronavirus Infections, business, Immune activation
Abstract

We read with interest the letter by D’Antiga evaluating the early experience with Coronavirus‐19 disease (COVID‐19) in liver transplant (LT) recipients in Bergamo and suggesting the absence of correlation between immunosuppression and severity of disease. We report two cases of early liver transplant recipients infected by SARS‐CoV‐2 with only mild clinical manifestations. On the contrary, long‐term recipients with comorbities showed a more aggressive course and worse prognosis. Considering the emerging evidence of the contribution of immune activation in the severity of the COVID‐19, immunosuppression may in part prevent a more aggressive course of the disease.

Published
2020
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12. New‐Onset Antibodies to Platelet Factor 4 Following Liver Transplantation From a Donor With Vaccine‐Induced Thrombotic Thrombocytopenia

Author

Valsecchi, Mila, primary, Lauterio, Andrea, additional, Crocchiolo, Roberto, additional, De Carlis, Riccardo, additional, Pugliano, Mariateresa, additional, Centonze, Leonardo, additional, Ferla, Fabio, additional, Zaniboni, Matteo, additional, Veronese, Silvio, additional, Podda, Gian Marco, additional, Belli, Luca, additional, Rossini, Silvano, additional, De Carlis, Luciano, additional, and Fumagalli, Roberto, additional

Published
2021
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14. Machine Perfusions in Liver Transplantation: The Evidence‐Based Position Paper of the Italian Society of Organ and Tissue Transplantation

Author

Ghinolfi, Davide, primary, Lai, Quirino, additional, Dondossola, Daniele, additional, De Carlis, Riccardo, additional, Zanierato, Marinella, additional, Patrono, Damiano, additional, Baroni, Stefano, additional, Bassi, Domenico, additional, Ferla, Fabio, additional, Lauterio, Andrea, additional, Lazzeri, Chiara, additional, Magistri, Paolo, additional, Melandro, Fabio, additional, Pagano, Duilio, additional, Pezzati, Daniele, additional, Ravaioli, Matteo, additional, Rreka, Erion, additional, Toti, Luca, additional, Zanella, Alberto, additional, Burra, Patrizia, additional, Petta, Salvatore, additional, Rossi, Massimo, additional, Dutkowski, Philippe, additional, Jassem, Wayel, additional, Muiesan, Paolo, additional, Quintini, Cristiano, additional, Selzner, Markus, additional, and Cillo, Umberto, additional

Published
2020
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20. Recurrence of hepatocellular carcinoma after liver transplantation presenting with massive intrahepatic bleeding

Author

V. Pirotta, Alessandro Giacomoni, Iacopo Mangoni, Andrea Lauterio, Luciano De Carlis, Matteo Donadon, Abdallah Slim, Donadon, M, Giacomoni, A, Lauterio, A, Slim, A, Pirotta, V, Mangoni, I, and De Carlis, L

Subjects
Male, medicine.medical_specialty, Carcinoma, Hepatocellular, medicine.medical_treatment, Hemorrhage, Liver transplantation, Gastroenterology, Internal medicine, medicine, Carcinoma, Hepatectomy, Humans, Embolization, Hematoma, Transplantation, Hepatology, business.industry, General surgery, Liver Neoplasms, Cancer, Middle Aged, medicine.disease, Embolization, Therapeutic, Primary tumor, Liver Transplantation, Treatment Outcome, Liver Neoplasm, Hepatocellular carcinoma, Surgery, Neoplasm Recurrence, Local, Tomography, X-Ray Computed, business, Human
Abstract

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and is reported to be the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Liver resection and transplantation are the only curative treatment modalities, even though both techniques are marked by a relatively high rate of tumor recurrence. Whenever tumor recurrence develops as a new nodule, several strategies are available for diagnosis and treatment. However, massive bleeding in a transplanted liver due to recurrent ruptured HCC has never been reported. This kind of presenting pattern has several concerns for diagnosis and treatment.

Published
2008
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21. Donor safety in living donor liver donation: An Italian multicenter survey

Author

Lauterio, Andrea, primary, Di Sandro, Stefano, additional, Gruttadauria, Salvatore, additional, Spada, Marco, additional, Di Benedetto, Fabrizio, additional, Baccarani, Umberto, additional, Regalia, Enrico, additional, Melada, Ernesto, additional, Giacomoni, Alessandro, additional, Cescon, Matteo, additional, Cintorino, Davide, additional, Ercolani, Giorgio, additional, Rota, Matteo, additional, Rossi, Giorgio, additional, Mazzaferro, Vincenzo, additional, Risaliti, Andrea, additional, Pinna, Antonio Daniele, additional, Gridelli, Bruno, additional, and De Carlis, Luciano, additional

Published
2016
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