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Lung cancer is often associated with a poor quality of life, as reflected by patient-reported outcome measures (PROMs). The aim of this paper is to describe and compare the PROMs that are available. In this manuscript, we review the impact of PROMs on the management of lung cancer. Quality of the study and risk of bias were assessed using the appraisal tools recommended by the Dutch Cochrane Center. Out of 51 studies included in this review, ten instruments were identified and categorized as either generic, cancer- or lung cancer-specific. PROMs are primarily applied in scientific research to compare the therapy outcomes and in drug development to support labeling claims. The interest for the routine use of PROMs in daily practice is growing, which has positive effects on the communication with the patient, mutual decision making and the monitoring and managing of the patient. Besides that, PROMs have an independent prognostic value for survival in lung cancer and economic evaluations can be conducted using their results. Electronic platforms simplify the implementation of PROMs in the daily clinic. The EORTC QLQ-C30 and its lung cancer-specific module QLQ-LC13 are the most frequently used instruments in lung cancer patients. PROMs have the potential to improve the quality of care with a proper implementation in the routine practice. PROMS are needed to value and understand the experience of the patient.

Introduction: Patients with advanced lung cancer expierence high physical symptom burden with substantial psychological distress. Early palliative care (EPC) addresses the complex suportive care needs improving QOL and mood. The mechanisms are uncertain. We examined wether coping strategy influences QOL in patients with depressive or anxiety symptoms. Materials and Methods: We conducted a multi-centre cross-sectional study o f patients with advanced lung cancer. 125 patients completed assessments of AOL (QLQ-C15-PAL), depressive and anxiety symptoms (HADS) and coming (brief COPE questionnaire). The data were analyzed by descreptive statistics. To determine whether coping strategy has a moderating effect on the relationship between mood and QOL, the interaction term between mood and coping strategy was added in a multiple regression model. Results: Positive reframing correlates with global QOL (r=.25, p Conclusion: Patients with advanced lung cancer using positive reframing as coping strategy experience higher QOL. Self-blame leads to more insomnia and worse emotional wellbeing. Anxious patients using emotional coping have higher QOL, those using denial have lower QOL. Patients with depressive symptoms using positive refraiming as coping strategy experience higer QOL. Providing skills to cope effectively could impact QOL in these patients.

Introduction: To evaluate quality of life of lung cancer patients, the European Organisation for research and treatment of cancer (EORTC) updated the former module LC13, which includes symptoms with targed therapy und surgery and is used together with the QLQ-C30. Recently the influence of gender especially in lung cancer is investigated. Aims and objectives: Hence we analyzed gender differences with the help of the questionnaire QLQ-C30 and LC 29. Methods: This is a prospective, non-interventional, multicentre study, which took place in nine different countries (Germany, Great Britain, Italy, Israel, Norway, Poland, Spain, Taiwan, Cyprus). To determinate gender differences we used covarianz analyses, in which gender was a fixed factor. Following covariates were included Tumor type, therapy approach (palliative vs curative), education, surgery vs radiochemotherapy, targed therapy vs radiochemotherapy, NSCLC stage IV vs all other stages, comorbidity (yes vs no) Results: 200 patients participated in this study (women n=82 and men n=118). Median age was 65 years. Most women were non smoker (n=17, 65.4%) in comparison to men (n=9, 34.5%). Women as well as men had a median Karnofsky Performance Status of 80%. The important clinical variables are shown in the table. Conclusions: In summery the data show that there is no significant gender difference in quality of life of lung cancer patients except the symptom “coughing”. Estimated marginal means

Background: A one year pilot study, starting in February 2016 was set up to establish the operational workflow, map patient characteristics and identify trouble shooting when implementing the ICHOM lung cancer Standard Set (Mak, ERJ 2016). Methods: Incident patients (pts) with treatment-naive lung cancer, 18 years or older, able to understand and speak Dutch and treated at UZA were included. Self-reporting was conducted via a web-based interface using questionnaires and individual case-mix variables according to ICHOM v1.0. At baseline, during treatment and in follow up pts received electronic invitations. Digitally naive pts completed paper forms. Results: An operational workflow was developed within the routine clinical workflow, collecting PROMs and case-mix variables. 62 pts were screened of which 22 participated. The other 40 were ineligible because of language barrier, previous therapy, confusion or logistic failure. 6 pts are in follow up and 6 deceased. 95% of pts was of Caucasian type (median age 67 y). There were no demographic differences as compared with the group of screen failures. Baseline characteristics showed that all ICHOM pts were (ex-)smokers. Pts reported comorbidities according to Charlson show a variety being present, of which heart diseases comprise 41%. Case-mix variables linked to the first treatment characteristics show an equal distribution of treatment intent. First treatments comprise surgery as well as chemotherapy, radiotherapy and chemoradiotherapy. Conclusion: The proposed workflow allows capture of all eligible pts. Point-of care registration of PROMs remains time-consuming.Updated follow-up PROM’s and outcome indicators will be presented at the meeting.