1. Long-term survival with erlotinib in advanced lung adenocarcinoma harboring synchronous EGFR G719S and KRAS G12C mutations.
- Author
-
Ricciuti B, Baglivo S, Ludovini V, Sidoni A, Metro G, Brambilla M, Siggillino A, Reda MS, Rebonato A, Maiettini D, and Chiari R
- Subjects
- Adenocarcinoma genetics, Adenocarcinoma mortality, Disease Progression, ErbB Receptors genetics, Humans, Lung Neoplasms genetics, Lung Neoplasms mortality, Male, Neoplasm Staging, Remission Induction, Survival Analysis, Time Factors, Adenocarcinoma drug therapy, Antineoplastic Agents therapeutic use, DNA Mutational Analysis methods, Erlotinib Hydrochloride therapeutic use, Lung Neoplasms drug therapy, Mutation genetics, Proto-Oncogene Proteins p21(ras) genetics
- Abstract
Although epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS) mutations were thought to be mutually exclusive in patients with non-small cell lung cancer (NSCLC), the development of high sensitive large-scale mutation analysis, has increasingly shown that activating EGFR mutations occasionally coexist with other dominant genetic alterations. Herein, we discuss the case of a patient with advanced NSCLC harboring both the uncommon EGFR G719S and the KRAS G12C mutations, who was treated for 9 years with erlotinib achieving a long-term survival. In light of their rarity, multiple mutations are very challenging for the decision of tyrosine kinase inhibitors (TKIs) treatment, especially when EGFR mutations occur together with mutations known to provide resistance to EGFR TKIs, such as KRAS., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF