At this peak a couple of years ago, Josef Penninger was one of the hottest, most charming scientists in the world. From his lab on Toronto's hospital row, Penninger, a fearless anarchist, loved to demolish accepted wisdom as he swooped over a stunningly broad scientific landscape--bone, pain, cancer, heart disease and the immune system.He churned out so many papers in the world's most prestigious scientific journals that for two years running, in 1999 and 2000, the trend-tracker 'Science Watch' said Penninger was among the world's most quoted scientific researchers. Penninger's boss was Tak Mak, the wiry, hard-driven 56-year-old Hong Kong immigrant who has won nearly every scientific prize, except for the Nobel, for his discovery of the holy grail of the immune system.