1. Engineering Cross-Linkable Plasmonic Vesicles for Synergistic Chemo-Photothermal Therapy Using Orthogonal Light Irradiation
- Author
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Shiyong Liu, Guhuan Liu, Jinming Hu, Kangning Zhu, and Guoying Zhang
- Subjects
Materials science ,Polymers and Plastics ,Vesicle ,Organic Chemistry ,technology, industry, and agriculture ,Nanotechnology ,02 engineering and technology ,Photothermal therapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,Colloidal gold ,Heat generation ,Amphiphile ,Polymersome ,Materials Chemistry ,Surface plasmon resonance ,0210 nano-technology ,Drug carrier - Abstract
Plasmonic vesicles combine the advantages of polymersomes and physiochemical properties of inorganic nanoparticles, exhibiting promising applications in theranostic nanovectors. However, although many of these plasmonic vesicles have been engineered as photothermal therapy (PTT) agents and drug carriers, they undergo structural destruction due to localized surface plasmon resonance (LSPR) effect. Notably, the disassembly of plasmonic vesicles leads to the burst release of encapsulated payloads and drastically decrease therapeutic efficacy. Herein, we report the fabrication of plasmonic vesicles that can be tracelessly cross-linked under 410 nm blue light irradiation, which can effectively avoid being disassembled when localized heat generation under light irradiation (e.g., 560 nm). Amphiphilic hybrid gold nanoparticles (AuNPs) functionalized with hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(2-((((2-nitrobenzyl)oxy)carbonyl)amino)ethyl methacrylate) (PNBOC) blocks were synthesized via ligan...
- Published
- 2018