1. 3D spin-lock imaging of human gliomas
- Author
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Usama Abo Ramadan, Juha Jääskeläinen, Teemu K. Peltonen, Raimo Sepponen, Jukka I. Tanttu, Anna Maija Häkkinen, Hannu J. Aronen, and Antti T. Markkola
- Subjects
Adult ,Gadolinium DTPA ,Male ,media_common.quotation_subject ,Biomedical Engineering ,Biophysics ,Contrast Media ,Imaging phantom ,030218 nuclear medicine & medical imaging ,Central nervous system disease ,03 medical and health sciences ,0302 clinical medicine ,Nuclear magnetic resonance ,Glioma ,Image Processing, Computer-Assisted ,medicine ,Humans ,Contrast (vision) ,Radiology, Nuclear Medicine and imaging ,Bovine serum albumin ,Aged ,media_common ,medicine.diagnostic_test ,biology ,Brain Neoplasms ,Phantoms, Imaging ,Chemistry ,Pulse (signal processing) ,business.industry ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,3. Good health ,Contrast medium ,biology.protein ,Female ,Nuclear medicine ,business ,030217 neurology & neurosurgery - Abstract
We investigated whether the simultaneous use of paramagnetic contrast medium and 3D on-resonance spin lock (SL) imaging could improve the contrast of enhancing brain tumors at 0.1 T. A phantom containing serial concentrations of gadopentetate dimeglumine (Gd-DTPA) in cross-linked bovine serum albumin (BSA) was imaged. Eleven patients with histologically verified glioma were also studied. T1-weighted 3D gradient echo images with and without SL pulse were acquired before and after a Gd-DTPA injection. SL effect, contrast, and contrast-to-noise ratio (CNR) were calculated for each patient. In the glioma patients, the SL effect was significantly smaller in the tumor than in the white and gray matter both before (p = 0.001, p = 0.025, respectively), and after contrast medium injection (p < 0.001, p < 0.001, respectively). On post-contrast images, SL imaging significantly improved tumor contrast (p = 0.001) whereas tumor CNR decreased slightly (p = 0.024). The combined use of SL imaging and paramagnetic Gd-DTPA contrast agent offers a modality for improving tumor contrast in magnetic resonance imaging (MRI) of enhancing brain tumors. 3D gradient echo SL imaging has also shown potential to increase tissue characterization properties of MR imaging of human gliomas.
- Published
- 1999