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MRI of the lungs using hyperpolarized helium-3 (³He) allows the determination of intrapulmonary oxygen partial pressures (pO2). The need to separate competing processes of signal loss has hitherto required two different imaging series during two different breathing maneuvers. In this work, a new imaging strategy to measure pO2 by a single series of consecutive scans is presented. The feasibility of the method is demonstrated in three healthy human volunteers. Maps and histograms of intrapulmonary pO2 are calculated. Changes in the oxygen concentration of the inhaled gas mixture are well reproduced in the histograms. Monte Carlo (MC) simulations of the temporal evolution of ³He hyperpolarization within the lungs were performed to evaluate the accuracy of this measurement technique, and its limitations. Magn Reson Med 47:105–114, 2002. © 2002 Wiley-Liss, Inc.

MRI of the lungs using hyperpolarized helium‐3 (3He) allows the determination of intrapulmonary oxygen partial pressures (pO2). The need to separate competing processes of signal loss has hitherto required two different imaging series during two different breathing maneuvers. In this work, a new imaging strategy to measure pO2by a single series of consecutive scans is presented. The feasibility of the method is demonstrated in three healthy human volunteers. Maps and histograms of intrapulmonary pO2are calculated. Changes in the oxygen concentration of the inhaled gas mixture are well reproduced in the histograms. Monte Carlo (MC) simulations of the temporal evolution of 3He hyperpolarization within the lungs were performed to evaluate the accuracy of this measurement technique, and its limitations. Magn Reson Med 47:105–114, 2002. © 2002 Wiley‐Liss, Inc.