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Purpose: To investigate the sequence‐specific impact of B1+ amplitude mapping on the accuracy and precision of permittivity reconstruction at 3T in the pelvic region. Methods: B1+ maps obtained with actual flip angle imaging (AFI), Bloch–Siegert (BS), and dual refocusing echo acquisition mode (DREAM) sequences, set to a clinically feasible scan time of 5 minutes, were compared in terms of accuracy and precision with electromagnetic and Bloch simulations and MR measurements. Permittivity maps were reconstructed based on these B1+ maps with Helmholtz‐based electrical properties tomography. Accuracy and precision in permittivity were assessed. A 2‐compartment phantom with properties and size similar to the human pelvis was used for both simulations and measurements. Measurements were also performed on a female volunteer's pelvis. Results: Accuracy was evaluated with noiseless simulations on the phantom. The maximum B1+ bias relative to the true B1+ distribution was 1% for AFI and BS and 6% to 15% for DREAM. This caused an average permittivity bias relative to the true permittivity of 7% to 20% for AFI and BS and 12% to 35% for DREAM. Precision was assessed in MR experiments. The lowest standard deviation in permittivity, found in the phantom for BS, measured 22.4 relative units and corresponded to a standard deviation in B1+ of 0.2% of the B1+ average value. As regards B1+ precision, in vivo and phantom measurements were comparable. Conclusions: Our simulation framework quantitatively predicts the different impact of B1+ mapping techniques on permittivity reconstruction and shows high sensitivity of permittivity reconstructions to sequence‐specific bias and noise perturbation in the B1+ map. These findings are supported by the experimental results. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the sequence-specific impact of B 1 + amplitude mapping on the accuracy and precision of permittivity reconstruction at 3T in the pelvic region., Methods: B 1 + maps obtained with actual flip angle imaging (AFI), Bloch-Siegert (BS), and dual refocusing echo acquisition mode (DREAM) sequences, set to a clinically feasible scan time of 5 minutes, were compared in terms of accuracy and precision with electromagnetic and Bloch simulations and MR measurements. Permittivity maps were reconstructed based on these B 1 + maps with Helmholtz-based electrical properties tomography. Accuracy and precision in permittivity were assessed. A 2-compartment phantom with properties and size similar to the human pelvis was used for both simulations and measurements. Measurements were also performed on a female volunteer's pelvis., Results: Accuracy was evaluated with noiseless simulations on the phantom. The maximum B 1 + bias relative to the true B 1 + distribution was 1% for AFI and BS and 6% to 15% for DREAM. This caused an average permittivity bias relative to the true permittivity of 7% to 20% for AFI and BS and 12% to 35% for DREAM. Precision was assessed in MR experiments. The lowest standard deviation in permittivity, found in the phantom for BS, measured 22.4 relative units and corresponded to a standard deviation in B 1 + of 0.2% of the B 1 + average value. As regards B 1 + precision, in vivo and phantom measurements were comparable., Conclusions: Our simulation framework quantitatively predicts the different impact of B 1 + mapping techniques on permittivity reconstruction and shows high sensitivity of permittivity reconstructions to sequence-specific bias and noise perturbation in the B 1 + map. These findings are supported by the experimental results., (© 2019 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.)