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The biologically important complexes of aluminium(III) and gallium(III) derived from 1-acetylferrocenehydrazinecarbothioamide (L1H) and 1-acetylferrocene carbodithioic acid (L2H) were prepared and investigated using a combination of microanalytical analysis, melting point, electronic, infrared, 1H NMR and 13C NMR spectral studies along with X-ray powder diffraction studies. Aluminium and gallium isopropoxides interact with the ligands in molar ratios of 1:1, 1:2 and 1:3 (metal:ligand), resulting in the formation of coloured products. The ligands are coordinated to aluminium(III) and gallium(III) via the azomethine nitrogen atom and the thiolic sulfur atom. On the basis of X-ray powder diffraction study, one of the representative gallium(III) complexes was found to have orthorhombic lattice, having the following lattice parameters: a=8.9200, b=14.6000 and c=7.0000. On the basis of the above studies, for the aluminium(III) and gallium(III) complexes, pentacoordinated structure for 1:1 complex and hexacoordinated structure for 1:2 and 1:3 complexes were assigned. The antimicrobial activities of the ligands and complexes were screened in vitro against bacteria Pseudomonas cepacicola and Bacillus substilis and fungi Collectatrichum capsici and Fusarium oxysporum. The complexes have higher activities than the free ligands do. In vivo studies of the ligands and their corresponding complexes have also been carried out to assess their antifertility activity. The results of these activities indicate the antiandrogenic nature of these complexes.

Reactions of 2-hydroxy-N-phenylbenzamide with semicarbazide hydrochloride and thiosemicarbazide resulted in the formation of new ketimines, semicarbazone and thiosemicarbazone of 2-hydroxy-N-phenylbenzamide, respectively. The organogermanium(IV) complexes have been synthesized by reacting trimethylgermanium chloride and triphenylgermanium chloride in a 1:1 molar ratio with these ketimines using microwave as well as conventional heating method for comparison purposes. The authenticity of these ligands and their complexes has been established on the basis of elemental analysis, melting point determinations, molecular weight determinations, infrared, 1H and 13C nuclear magnetic resonance, ultraviolet, and mass spectral studies. These studies showed that the ketimines coordinated with the germanium atom and, accordingly, the trigonal bipyramidal environment around the metal atom has been established for the complexes. Both the ketimines and their complexes have been screened for their antimicrobial activities against a variety of fungal and bacterial strains and were found positive in this respect. The pesticidal activity of both the ligands and their metal complexes against the Corcyra cephalonica has also been tested.