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Introdution: Ageing is associated with systemic inflammation. MicroRNA-146a (miR-146a) is a critical negative regulator of inflammation and its level was found to decrease with ageing. The aim of this study was to analyze the effect of regular brisk walking on blood circulating levels of miR-146a and plasma levels of Interlukine-6 (IL-6) in sedentary elderly women. Methods: In this quasi-experimental study, 20 aged women (63.5±3.9 years) were randomly allocated to the endurance training (n=10), and control groups (n=10). Training group (TG) walked at 70-75% maximum heart rate reserve (HRRmax), three times a week for twelve weeks. Control group remained untrained during the study period. Blood samples were collected before and 72 hours after the last session of endurance training for measuring concentration of miR-146a and IL-6. Independent T-test, Paired T-test, Mann Whitney, and Wilcoxon were used after the data analysis base on normalization. Statistical analysis was performed using SPSS software version 24 and the significant level was set at P≤0.05. Results: The results revealed that the levels of miR-146a increased (P=0.027) and the levels of IL-6 decreased (P=0.001) significantly in response to the endurance training protocol, and these changes were associated with a decrease in body mass index (BMI) (P=0.002). Conclusion: According to the result of the present study, brisk walking training may be considered as an effective training mode for helping to decrease the blood inflammatory factors. The findings also suggest that microRNAs can be improved, after regular walking, in old adult