1. Multiomics Analyses Explore the Immunometabolic Interplay in the Liver of White Crucian Carp (Carassius cuvieri) After Aeromonas veronii Challenge.
- Author
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Wang F, Zhong ZR, Xie Q, Ou J, Xiong NX, Huang MZ, Li SY, Hu G, Qin ZL, and Luo SW
- Subjects
- Animals, Amino Acids metabolism, Transcriptome, Multiomics, Aeromonas veronii, Gram-Negative Bacterial Infections veterinary, Gram-Negative Bacterial Infections immunology, Gram-Negative Bacterial Infections microbiology, Carps microbiology, Carps immunology, Carps metabolism, Carps genetics, Liver metabolism, Fish Diseases immunology, Fish Diseases microbiology, Fish Diseases metabolism
- Abstract
Aeromonas veronii is one of the predominant pathogenic species that can imperil the survival of farmed fish. However, the interactive networks of immune regulation and metabolic response in A. veronii-infected fish are still unclear. In this investigation, we aimed to explore immunometabolic interplay in white crucian carp (WCC) after the A. veronii challenge. Elevated levels of immune-related genes were observed in various tissues after A. veronii infection, along with the sharp alteration of disease-related enzymatic activities. Besides, decreased levels of antioxidant status were observed in the liver, but most metabolic gene expressions increased dramatically. Multiomics analyses revealed that metabolic products of amino acids, such as formiminoglutamic acid (FIGLU), L-glutamate (L-Glu), and 4-hydroxyhippuric acid, were considered the crucial liver biomarkers in A. veronii-infected WCC. In addition, A. veronii infection may dysregulate endoplasmic reticulum (ER) function to affect the metabolic process of lipids, carbohydrates, and amino acids in the liver of WCC. These results may have a comprehensive implication for understanding immunometabolic response in WCC upon A. veronii infection., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
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