1. 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34
- Author
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Fang, Fang, Zhao, Jiaying, Ding, Lijian, Huang, Chunhui, Naman, C Benjamin, He, Shan, Wu, Bin, Zhu, Peng, Luo, Qijun, Gerwick, William H, Yan, Xiaojun, Wang, Qinwen, Zhang, Zaijun, and Cui, Wei
- Subjects
Neurodegenerative ,Brain Disorders ,Amyloid ,Animals ,Biphenyl Compounds ,Cell Line ,Circular Dichroism ,Cyclopentanes ,Free Radical Scavengers ,Humans ,Phytotherapy ,Picrates ,Porifera ,Trichoderma ,sponge-derived fungus ,cyclopentenone ,Trichoderma sp HPQJ-34 ,Alzheimer's disease ,Alzheimer’s disease ,Trichoderma sp. HPQJ-34 ,Physical Chemistry (incl. Structural) ,Pharmacology and Pharmaceutical Sciences ,Medicinal & Biomolecular Chemistry - Abstract
Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease β-amyloid (Aβ) fibrillization in vitro. Moreover, 1 significantly reduced H₂O₂-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-Aβ fibrillization properties and neuroprotective effects, and might be a good free radical scavenger.
- Published
- 2017