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The article describes an automated calculation of such an essential part of a centrifugal pumps the rotor shaft, so the highest level CAD NASTRAN system PATRAN module was used for the analysis. The computational mechanical scheme was drawn up, the axial and radial force acting on the impeller and the pump shaft were determined. The stress for the maximum feed case are determined. The results of the automated strength calculation were used for further analysis of the service life of the rotor shaft of a centrifugal pump. A computer technique for determining the service life of the shaft is given, taking into account the technological, mechanical conditions of operation and taking into account the projected service life equal to the lifetime of the uranium well. Using the automated MSC FATIGUE module, the number of loading cycles was determined, the service life safety factor was determined, which showed the efficiency of the pump throughout the entire operating time of the uranium well.