1. Aminopropyl-silica functionalized with halogen-reactive compounds for antimicrobial applications.
- Author
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Zarafu, Irina, Jebur Al Taweel, Ali Abed, Limban, Carmen, Popa, Marcela, Măruțescu, Luminița, Chifiriuc, Mariana Carmen, Pircalabioru, Gratiela Gradisteanu, Culiță, Daniela, Ghica, Corneliu, and Ionita, Petre
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BIOLOGICAL assay , *ENTEROCOCCUS faecalis , *ORGANIC compounds , *PSEUDOMONAS aeruginosa , *CANDIDA albicans , *ENTEROCOCCUS , *MUPIROCIN - Abstract
Aminopropyl-silica nanoparticles S0 were obtained and further functionalized with eight halogen-reactive organic compounds 1–8 , leading to the S1–S8 hybrid organic-inorganic materials, with spherical morphology and having a 50–200 nm size, as showed TEM analysis. These were further characterized by IR and DLS. Biological assays were performed using five microbial strains, belonging to species frequently encountered in the aetiology of human infections (Enterococcus faecalis, Staphylococcus aureus , Pseudomonas aeruginosa, Escherichia coli and Candida albicans). The obtained materials exhibited promising antimicrobial properties, being active against planktonic, but particularly on biofilm-embedded cells. Among the tested hybrid nanomaterials, S6 seemed to exhibit the most promising antimicrobial profile. Image 1 • Aminopropyl-silica nanoparticles synthetized. • Functionalized with 8 halogeno-reactive organic compounds. • Characterised by IR, TEM, DLS. • Biological assays were performed using five microbial strains. • Active both against planktonic and biofilm-embedded cells. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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