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• The nanofibrous diameter increased with increasing CEX concentration. • The nanofibrous possessed a great potential to take up water and tensile strength. • PCL/GelMA-CEX has a great inhibition against E. coli and S. aureus bacteria. • PCL/GelMA loading with low CEX concentration possessed great biocompatibility. • Wound healing process was enhanced with the PCL/GelMA-CEX nanofibrous. Infections, particularly those induced via drug resistant pathogens, can cause serious issues in wound healing process. In this study, cephalexin (CEX), as an effective antibiotic, was loaded into polycaprolactone (PCL)-gelatin methacryloyl (GelMA) nanofibrous by electrospinning for the development of a new wound dressing. The electrospun nanofibrous possessed continuous and smooth structure with the fiber diameters ranging from 280 to 330 nm. Swelling examination exhibited that the electrospun nanofibrous could take up water by 400–600%. Antibacterial activity of PCL/GelMA loading with CEX had a great inhibition towards both Gram-positive Staphylococcus aureus and negative-bacteria Escherichia coli. The hematoxylin-eosin (H&E) and Masson's trichrome (MT) staining results from treated wounds with PCL/GelMA-CEX nanofibrous exhibited improved re-epithelialization and collagen deposition. Taken together, our study illustrate the PCL/GelMA-CEX nanofibrous can be promising for use as an effective antibacterial wound dressing in skin regeneration. [ABSTRACT FROM AUTHOR]

One of the most important therapeutic and economic concerns regarding surgery, is the occurrence of post-operative infections which leads to an increase in premature failure rate. Therefore, novel nanostructured baghdadite-vancomycin (Ba-Vac) scaffolds were prepared using the space holder method with good mechanical properties and controlled drug release to inhibit post-surgery infections. The results showed that the (Ba-Vac) scaffolds were attained with the pore size of 300–400 µm and total porosity of 80–82% with compressive strength of 0.86–0.88 MPa. In drug release profiles, a burst release was observed for 6 h, followed by a sustained release. Ba-Vac scaffolds presented good antibacterial activity toward Staphylococcus aureus ( S. aureus ). More attachment and spreading of MG-63 osteoblast cells on the Ba and Ba-(1-3 wt%)Vac scaffolds was also observed in comparison with the Ba-5 wt%Vac scaffold. Therefore, the Ba-(1–3 wt%)Vac scaffold is a good candidate for inhibiting post-surgery infections, as well as for bone tissue engineering. [ABSTRACT FROM AUTHOR]