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Current discussion is to evaluate the influence of wall properties on thermal and flow performance, through a sinusoidal inclined wavy tube. To fulfill this phenomena we consider a sinusoidal tube having wavy walls, furthermore silicon-dioxide, ferrosoferric-oxide and zinc-oxide are treated as nano-particles and combination of 40% C 2 H 6 O 2 and 60% H 2 O as a base-fluid, but after the literature review we have seen that Iftikhar et al. (2018) presented the consequence of wall properties on copper–water nano-fluid through inclined tube. The out-coming arithmetical results are simplified with the assist of mathematica and perturbation method. Further-more, we graphically evaluate the thermal and flow performance of nanofluids at different rate of solid volume fractions (ϕ) , rigidity parameter (E 1) , Grashof number (G r) , slip parameter (γ) and heat generation parameter. we observed that Solid volume fraction (ϕ) of silicon dioxide, ferrosoferric oxide and zinc oxide causes the reduction of velocity profile. And velocity profile shows the opposite behavior corresponding to (E 1) and (G r). Temperature profile θ (r , t) decreases by developing the amount of (ϕ) for silicon dioxide, ferrosoferric oxide and zinc oxide, and temperature profile moves upward corresponding to heat parameter B. • Wall properties and thermal behavior of nano-fluids flow over an inclined sinusoidal wavy pipe is assumed. • Silicon-dioxide, ferrosoferric -oxide and zinc-oxide are treated as nano-particles and combination of 40% ethylene-glycol and 60% water as a base fluid. • We assume a sinusoidal wavy surface. • The problem is solved by using Mathematica. [ABSTRACT FROM AUTHOR]