1. NIR/pH dual-responsive polysaccharide-encapsulated gold nanorods for enhanced chemo-photothermal therapy of breast cancer.
- Author
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Xu, Weijun, Wang, Jinlei, Qian, Junmin, Hou, Guanghui, Wang, Yaping, Ji, Lijie, and Suo, Aili
- Subjects
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BREAST cancer , *HYALURONIC acid , *CANCER treatment , *NANORODS , *SCHIFF bases , *GOLD nanoparticles - Abstract
Combination of different therapy modalities with multiple tumoricidal mechanisms has emerged as a promising anticancer strategy. Herein, we reported an aldehyde/catechol-functionalized hyaluronic acid (DAHA) and hydroxyethyl chitosan (HECS) decorated gold nanorod (GNR) platform for combined chemo-photothermal therapy of breast cancer. The DAHA was synthesized by conjugating dopamine onto oxidized hyaluronic acid. The nanoplatform was prepared by successively modifying GNR with DAHA via Au-catechol bonds, conjugating DOX onto DAHA moiety through Schiff base linkage, and coating HECS interlayer for charge-reversal and hyaluronic acid corona for tumor cell targeting. The resulting nanoplatform GNR-HADOXCH exhibited acid-triggered surface charge-reversal and pH/NIR dual-responsive drug release behaviors. The nanoplatform could be efficiently internalized into MCF-7 breast cancer cells and displayed greater cancer cell killing than individual modalities. Therefore, polysaccharide decoration could ensure the co-delivery of GNR and DOX into cancer cells, and the developed GNR-HADOXCH holds great potential for breast cancer treatment. Unlabelled Image • The versatile nanoplatform was prepared via a facile and effective self-assembly method. • The nanoplatform exhibited acid-triggered surface charge-reversal property. • The nanoplatform had pH/NIR dual-responsive drug release behavior. • Receptor recognition and charge-reversal dual-enhanced cellular internalization. • MCF-7 cells could be efficiently killed by combined chemo-photothermal therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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