1. Mg/Cu-doped TiO2 nanotube array: A novel dual-function system with self-antibacterial activity and excellent cell compatibility.
- Author
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Wang, Bingbing, Wu, Zongze, Wang, Shuo, Wang, Saisai, Niu, Qimeng, Wu, Yuwei, Jia, Fenghuan, Bian, Anqi, Xie, Lei, Qiao, Haixia, Chang, Xiaotong, Lin, He, Zhang, Hui, and Huang, Yong
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TITANIUM , *TITANIUM dioxide , *SURFACE coatings , *COPPER-titanium alloys , *SURFACE morphology , *MAGNESIUM , *CYTOCOMPATIBILITY , *BODY fluids - Abstract
Many studies were conducted to change the surface morphology and chemical composition of Ti implants for the improvement of antibacterial ability and osseointegration between medical Ti and surrounding bone tissue. In this study, we successfully prepared a novel dual-function coating on pure Ti surface, i.e. Cu and Mg-co-doped TiO 2 nanotube (TN) coating, by combining anodisation and hydrothermal treatment (HT), which could act as a delivery platform for the sustained release of Cu and Mg ions. Results showed that the amounts of Cu and Mg were about 5.43 wt%–6.55 wt% and 0.69 wt%–0.73 wt%, respectively. In addition, the surface morphology of Cu and Mg-co-doped TN (CuMTN) coatings transformed into nanoneedles after HT for 1 h. Compared with TN, CuMTN had no change in roughness and remarkable improved hydrophilicity. Antibacterial tests revealed that CuMTN had an antibacterial rate of more than 93% against Escherichia coli and Staphylococcus aureus , thereby showing excellent antibacterial properties. In addition, CuMTN could induce the formation of apatite well after being immersed in simulated body fluid, showing good biological activity. Preosteoblasts (MC3T3-E1) cultured on CuMTN-coated Ti demonstrated better proliferation and osteogenic differentiation than pristine and as-anodised specimens. To the best of our best knowledge, this study had successfully attempted to combine anodisation and HT, introduce Cu/Mg elements and functionalise Ti-based implant surfaces with enhanced hydrophilicity, osteogenesis and antimicrobial properties that can meet clinical needs for the first time. • The copper and magnesium co-doped TN (CuMTN) were prepared. • The nanostructure can slow down the release rate of Mg and Cu. • The coating had an exceptional antimicrobial effect on S. aureus and E. coli. • The coating can induce the formation of new apatite. • The coating showed exceptional cytocompatibility and osseointegration. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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