1. A gelatin composite scaffold strengthened by drug-loaded halloysite nanotubes.
- Author
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Ji, Lijun, Qiao, Wei, Zhang, Yuheng, Wu, Huayu, Miao, Shiyong, Cheng, Zhilin, Gong, Qianming, Liang, Ji, and Zhu, Aiping
- Subjects
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NANOTUBES , *BONE grafting , *SCAFFOLD proteins , *HALLOYSITE , *GELATIN , *EQUIPMENT & supplies , *THERAPEUTICS - Abstract
Mechanical properties and anti-infection are two of the most concerned issues for artificial bone grafting materials. Bone regeneration porous scaffolds with sustained drug release were developed by freeze-drying the mixture of nanosized drug-loaded halloysite nanotubes (HNTs) and gelatin. The scaffolds showed porous structure and excellent biocompatibility. The mechanical properties of the obtained composite scaffolds were enhanced significantly by HNTs to > 300%, comparing to those of gelatin scaffold, and match to those of natural cancellous bones. The ibuprofen-loaded HNTs incorporated in the scaffolds allowed extended drug release over 100 h, comparing to 8 h when directly mixed the drug into the gelatin scaffold. The biological properties of the composite scaffolds were investigated by culturing MG63 cells on them. The HNTs/gelatin scaffolds with excellent mechanical properties and sustained drug release could be a promising artificial bone grating material. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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