Search

Local delivery of antibiotics utilising bone cement is a well-known approach for controlling postoperative infections related to implant. 1, 5 and 10 wt.% of clindamycin (Cli) was embedded into polymethylmethacrylate (PMMA)–based bone cement for inhibiting postsurgical infection. Clindamycin antibiotic drug was homogeneously embedded into the matrix of PMMA-based cement. The results revealed that the fabricated PMMA-based cement loaded with Cli presented a high compressive strength (~120 MPa). The PMMA-based cement loaded with low Cli presented better cytocompatibility compared with its counterpart loaded with high Cli owing to the better cell attachment on the surface of the cement with a lower release of Cli. The embedding of Cli into the cement improved its antibacterial performance, as implied by the considerably improved inhibition zone with amplifying Cli concentration. Taken together, PMMA-based cement loaded with 1–5 wt% Cli might be a promising antimicrobial bone cement to be employed in orthopaedic surgeries. [ABSTRACT FROM AUTHOR]

Ti alloy has been widely employed in the creation of implants for various dentistry and orthopedic applications, but is limited by its inadequate bioactivity. This paper presents our study on the electrophoretic deposition of bioglass/graphene oxide (BG-GO) composites on Ti-alloy implants to improve antibacterial and cytocompatible properties. The BG-GO composites created a uniform and compact coating layer with a thickness of 50-55 μm that was able to improve corrosion resistance compared to samples coated with BG only. Higher antibacterial activity was observed for the specimens coated with BG-GO vs. BG only, and the antibacterial activity of the BG-GO coating increased with GO content. Cell adhesion results showed the BG-GO composite coating had good biocompatibility and that the incorporation of GO in the BG-GO coating did not hinder cell attachment to the alloy sample. Therefore, BG-GO composite coatings prepared using the EPD method with the aforementioned properties can serve as an effective alternative for bone implant applications. [ABSTRACT FROM AUTHOR]

In the present study, porous magnesium-xzeolite (x= 0, 3, 5 and 7 wt.%) composite scaffolds containing different amounts of zeolite were synthesized through combination of powder metallurgy (PM) and space holder (SH) techniques. The findings demonstrated that incorporation of zeolite into Mg composite scaffolds leads to higher compressive strength and corrosion resistance than Mg scaffolds without Zeo. Moreover, the Mg/Zeo composite scaffold presented good bioactivity, high capability in MG63 cell attachment and viability whereas a smaller number of cells could attach to the Mg scaffold without Zeo. The antibacterial response of these Mg/Zeo-Ag composite scaffolds against Gram-positive Staphylococcus aureus (S. aureus) and Gram negative Escherichia coli (E. coli) indicates the positive role of silver-zeolite in suppressing the bacteria growth. The aforementioned tests indicated that the articulated magnesium composite scaffold containing 7 wt.% Zeo with suitable mechanical strength and excellent biological activity may be considered as a promising biomaterial for bone substitution. [ABSTRACT FROM AUTHOR]